WB, IHC-Pmore details Unsuitable for:
Flow Cyt,ICC or IP
Mouse, Rat, Human
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human H6PD aa 750 to the C-terminus (Cysteine residue). The exact sequence is proprietary. Database link: O95479
Fetal liver, MCF-7, rat liver, HepG2 and mouse liver lysates; Human kidney and stomach tissue.
This product is a recombinant rabbit monoclonal antibody.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates.
Present in most tissues examined, strongest in liver.
Involvement in disease
Defects in H6PD are a cause of cortisone reductase deficiency (CRD) [MIM:604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
In the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family. In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.