HA1 (H9N2) full length protein (ab67740)

Overview

  • Product nameHA1 (H9N2) full length protein

Description

  • NatureRecombinant
  • SourceBaculovirus infected insect cells
  • Amino Acid Sequence
    • Amino acids0 to 0

Specifications

Our Abpromise guarantee covers the use of ab67740 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Purity> 90 % by SDS-PAGE.
    sterile filtered.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 0.01% Tween 20, 150mM Sodium chloride, 10mM Sodium phosphate, pH 7.0

General info

  • Alternative names
    • Hemagglutinin
  • RelevanceHemagglutinin (HA) is a class I viral fusion protein from the Influenza virus. It is a major glycoprotein, comprising over 80% of the envelope proteins present in the virus particle. HA binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell, and is responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. The HA protein is a homotrimer of disulfide-linked HA1-HA2. It also plays a major role in the determination of host range restriction and virulence. Genetic variation of hemagglutinin and/or neuraminidase genes results in the emergence of new influenza strains. Influenza A subtypes are classified based on the combination of the virus coat glycoproteins, hemagglutinin (HA) and neuraminidase (NA). H9N2 influenza A viruses circulate worldwide. Since the mid-1990s, H9 viruses have become adapted to land-based birds and have crossed sporadically to pigs and humans, causing mild respiratory disease. Importantly, some of the currently circulating H9N2 viruses bind to sialic acid receptors linked to galactose in the {alpha}-2,6 conformation, which is the preferential binding pattern of human influenza viruses. Thus, these H9N2 viruses possess one of the key elements needed to establish stable lineages in humans.
  • Cellular localizationviral envelope; apical plasma membrane. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts (By similarity).

References for HA1 (H9N2) full length protein (ab67740)

ab67740 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your inquiry. The protein is made in SF+ cells - a proprietary cell line. Also, the cell media is serum free. I hope this information helps. Please contact us with any other questions.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"