• Product nameAnti-Hamartin antibody
    See all Hamartin primary antibodies
  • Description
    Rabbit polyclonal to Hamartin
  • SpecificityThis antibody will recognise both isoforms of TSC1.
  • Tested applicationsSuitable for: ICC/IF, WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide - a 15 amino acid peptide from the middle region of human TSC1 (Human). Peptide available as ab95277.

  • Positive control
    • EL4 cell lysate can be used as positive control



Our Abpromise guarantee covers the use of ab25882 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 2 µg/ml.
WB Use a concentration of 1 µg/ml. Detects a band of approximately 130 kDa (predicted molecular weight: 130 kDa).


  • FunctionIn complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.
  • Tissue specificityHighly expressed in skeletal muscle, followed by heart, brain, placenta, pancreas, lung, liver and kidney. Also expressed in embryonic kidney cells.
  • Involvement in diseaseDefects in TSC1 are the cause of tuberous sclerosis type 1 (TSC1) [MIM:191100]. It is an autosomal dominant multi-system disorder that affects especially the brain, kidneys, heart, and skin. TS1C is characterized by hamartomas (benign overgrowths predominantly of a cell or tissue type that occurs normally in the organ) and hamartias (developmental abnormalities of tissue combination). Clinical symptoms can range from benign hypopigmented macules of the skin to profound mental retardation with intractable seizures to premature death from a variety of disease-associated causes.
    Defects in TSC1 may be a cause of focal cortical dysplasia of Taylor balloon cell type (FCDBC) [MIM:607341]. FCDBC is a subtype of cortical displasias linked to chronic intractable epilepsy. Cortical dysplasias display a broad spectrum of structural changes, which appear to result from changes in proliferation, migration, differentiation, and apoptosis of neuronal precursors and neurons during cortical development.
  • DomainThe C-terminal putative coiled-coil domain is necessary for interaction with TSC2.
  • Post-translational
    Phosphorylation at Ser-505 does not affect interaction with TSC2. Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationCytoplasm. Membrane. At steady state found in association with membranes.
  • Information by UniProt
  • Database links
  • Alternative names
    • Hamartin antibody
    • kiaa0243 antibody
    • LAM antibody
    • TSC antibody
    • Tsc1 antibody
    • Tsc1 gene antibody
    • TSC1_HUMAN antibody
    • Tuberous sclerosis 1 antibody
    • Tuberous sclerosis 1 protein antibody
    • tumor suppressor antibody
    see all

Anti-Hamartin antibody images

  • All lanes : Anti-Hamartin antibody (ab25882) at 1 µg/ml

    Lane 1 : EL4 cell lysate with absence of blocking peptide
    Lane 2 : EL4 cell lysate with presence of blocking peptide

    Predicted band size : 130 kDa
    Observed band size : 130 kDa
  • ab25882 at 2µg/ml staining Hamartin in EL4 cells by ICC/IF

References for Anti-Hamartin antibody (ab25882)

ab25882 has not yet been referenced specifically in any publications.

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