Anti-HAND1 antibody (ab115256)

Overview

• Product nameAnti-HAND1 antibody
  See all HAND1 primary antibodies
• Description
  Rabbit polyclonal to HAND1
• Tested applicationsSuitable for: ELISA, IHC-Pmore details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Rat, Sheep, Rabbit, Horse, Cow, Dog, Pig
• Immunogen

  Synthetic peptide:

  QHEGFPPALGPVEK

  conjugated to KLH, corresponding to amino acids 183-196 of Human HAND1
  Run BLAST with Run BLAST with
• Positive control
  • Human Heart tissue

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term.
• Storage bufferPreservative: 0.01% Sodium azide
  Constituent: 99% PBS
• Concentration information loading...
• PurityProtein G purified
• ClonalityPolyclonal
• IsotypeIgG
• Research areas
  • Epigenetics and Nuclear Signaling
  • Transcription
  • Other factors

  • Stem Cells
  • Lineage Markers
  • Ectoderm

  • Cardiovascular
  • Heart
  • Cardiogenesis
  • Transcription factors/regulators

  • Developmental Biology
  • Lineage specification
  • Ectoderm

Associated products

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

Applications

Target

• FunctionTranscription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box).
• Tissue specificityHeart.
• Sequence similaritiesContains 1 basic helix-loop-helix (bHLH) domain.
• Post-translational
  modificationsPhosphorylation by PLK4 disrupts the interaction with MDFIC and leads to tranlocation into the nucleoplasm, allowing dimerization and transcription factor activity.
• Cellular localizationNucleus > nucleoplasm. Nucleus > nucleolus. Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity.

• Target information above from: UniProt accession O96004 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 9421 Human
  • Entrez Gene: 59112 Rat
  • Omim: 602406 Human
  • SwissProt: O96004 Human
  • SwissProt: P57100 Rabbit
  • SwissProt: P97832 Rat
  • SwissProt: Q28555 Sheep
  • Unigene: 152531 Human

  • Unigene: 224598 Rat
  • Unigene: 39340 Rat

  see all
• Alternative names
  • autonomic nervous system and neural crest derivatives-expressed protein 1 antibody
  • Basic helix loop helix transcription factor HAND1 antibody
  • bHLHa27 antibody

  • Class A basic helix-loop-helix protein 27 antibody
  • eHAND antibody
  • Extraembryonic tissues antibody
  • Extraembryonic tissues heart autonomic nervous system and neural crest derivatives expressed protein 1 antibody
  • HAND 1 antibody
  • HAND1 antibody
  • HAND1_HUMAN antibody
  • Heart and neural crest derivatives expressed 1 antibody
  • Heart and neural crest derivatives expressed protein 1 antibody
  • heart antibody
  • Heart- and neural crest derivatives-expressed protein 1 antibody
  • Hxt antibody
  • Thing 1 antibody
  • Thing1 antibody
  • Thing1 antibody

  see all