Overview

  • Product nameAnti-Haptoglobin antibody
    See all Haptoglobin primary antibodies
  • Description
    Rabbit polyclonal to Haptoglobin
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rabbit
  • Immunogen

    Recombinant fragment containing a sequence corresponding to a region within amino acids 129-375 of Human Haptoglobin (UniProt: P00738).

  • Positive control
    • HeLa whole cell lysate; H1299 and HepG2 cell lysates.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage bufferPreservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab97969 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 38 kDa.
ELISA Use at an assay dependent concentration. PubMed: 24195779

Target

  • FunctionAs a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
    Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
  • Tissue specificityExpressed by the liver and secreted in plasma.
  • Involvement in diseaseAnhaptoglobinemia
  • Sequence similaritiesBelongs to the peptidase S1 family.
    Contains 1 peptidase S1 domain.
    Contains 2 Sushi (CCP/SCR) domains.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Binding peptide antibody
    • BP antibody
    • Haptoglobin alpha chain antibody
    • Haptoglobin alpha(1S) beta antibody
    • Haptoglobin alpha(2FS) beta antibody
    • Haptoglobin beta chain antibody
    • Haptoglobin, alpha polypeptide antibody
    • Haptoglobin, beta polypeptide antibody
    • HP antibody
    • HP2 ALPHA2 antibody
    • HP2ALPHA2 antibody
    • HPA1S antibody
    • HPT antibody
    • HPT_HUMAN antibody
    • MGC111141 antibody
    • Zonulin antibody
    see all

Anti-Haptoglobin antibody images

  • Anti-Haptoglobin antibody (ab97969) at 1/500 dilution + HeLa whole cell lysate at 30 µg

    Predicted band size : 38 kDa

References for Anti-Haptoglobin antibody (ab97969)

This product has been referenced in:
  • Liu LY  et al. Integrating multiple 'omics' analyses identifies serological protein biomarkers for preeclampsia. BMC Med 11:236 (2013). ELISA ; Human . Read more (PubMed: 24195779) »

See 1 Publication for this product

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The immunogen covers both alpha and beta chain and we therefore cannot find out if the antibody binds in both chains or not. (This might also be di...

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