Overview

  • Product nameHarmane
  • Description
    β-Carboline. Imidazoline ligand. MAO inhibitor.
  • Biological descriptionNanomolar affinity for the I1-imidazoline receptor (IC50 = 30 nM). Endogenous to the brain. Able to cross the blood-brain barrier. Active at I1, I2 and I3 binding sites, 1000-fold selectivity for I1 over α2 adrenoceptors. Known MAO-A inhibitor.
  • Purity> 99%

Properties

    References for Harmane (ab120605)

    This product has been referenced in:
    • Farzin D  et al. Effects of harmane and other ß-carbolines on apomorphine-induced licking behavior in rat. Pharmacol Biochem Behav 98:215-9 (2011). Read more (PubMed: 21237191) »
    • Anderson NJ  et al. In vitro and ex vivo distribution of [3H]harmane, an endogenous beta-carboline, in rat brain. Neuropharmacology 50:269-76 (2006). Read more (PubMed: 16242163) »
    • Musgrave IF & Badoer E Harmane produces hypotension following microinjection into the RVLM: possible role of I(1)-imidazoline receptors. Br J Pharmacol 129:1057-9 (2000). Read more (PubMed: 10725251) »

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