Overview

  • Product name
    Harmine
  • Description
    Potent and selective inhibitor of DYRK1A
  • Biological description
    Potent and selective inhibitor of DYRK1A (dual specificity tyrosine-phosphorylated and -regulated kinase). (IC50 values are 0.08 (DYRK1A), 0.9 (DYRK2), 0.8 (DYRK3), 4.3 (PIM3) and 1.5 μM (CK1)). 5-HT antagonist and MAO inhibitor. Regulator of PPARγ expression and antidiabetic.
  • Purity
    > 98%

Properties

  • Chemical name
    7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole
  • Molecular weight
    212.25
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C13H12N2O
  • CAS Number
    442-51-3
  • PubChem identifier
    5280953
  • Storage instructions
    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    COc1ccc3c(c1)nc2c3ccnc2C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Waki H  et al. The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression. Cell Metab 5:357-70 (2007). Read more (PubMed: 17488638) »
  • Bain J  et al. The selectivity of protein kinase inhibitors: a further update. Biochem J 408:297-315 (2007). Read more (PubMed: 17850214) »
  • Song Y  et al. Specific inhibition of cyclin-dependent kinases and cell proliferation by harmine. Biochem Biophys Res Commun 317:128-32 (2004). Read more (PubMed: 15047157) »

See 0 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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