Overview

  • Product nameAnti-HAX1 antibody
    See all HAX1 primary antibodies
  • Description
    Rabbit polyclonal to HAX1
  • SpecificityAt least four isoforms of HAX1 are known to exist. ab78939 is expected to recognize the longest isoform (HAX1a) as well as the shortest.
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A 15 amino acid synthetic peptide near the amino terminus of human HAX1.

  • Positive control
    • Human Brain Tissue Lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab78939 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 32 kDa.
ELISA Use at an assay dependent dilution.

Target

  • FunctionPromotes cell survival. Potentiates GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. May regulate intracellular calcium pools.
  • Tissue specificityUbiquitous. Up-regulated in oral cancers.
  • Involvement in diseaseDefects in HAX1 are the cause of neutropenia severe congenital autosomal recessive type 3 (SCN3) [MIM:610738]; also known as Kostmann disease. A disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections. Some patients affected by severe congenital neutropenia type 3 have neurological manifestations such as psychomotor retardation and seizures. Note=The clinical phenotype due to HAX1 deficiency appears to depend on the localization of the mutations and their influence on the transcript variants. Mutations affecting exclusively isoform 1 are associated with isolated congenital neutropenia, whereas mutations affecting both isoform 1 and isoform 5 are associated with additional neurologic symptoms.
  • Sequence similaritiesBelongs to the HAX1 family.
  • Post-translational
    modifications
    Proteolytically cleaved by caspase-3 during apoptosis.
  • Cellular localizationMitochondrion. Endoplasmic reticulum. Nucleus membrane. Cytoplasmic vesicle. Sarcoplasmic reticulum.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ17042 antibody
    • FLJ18492 antibody
    • FLJ93803 antibody
    • HAX 1 antibody
    • HAX-1 antibody
    • HAX1 antibody
    • HAX1_HUMAN antibody
    • Hax1a antibody
    • HCLS1 and PKD2 associated protein antibody
    • HCLS1 associated protein antibody
    • HCLS1 associated protein X 1 antibody
    • HCLS1-associated protein X-1 antibody
    • HCLSBP1 antibody
    • HS 1 associated protein X 1 antibody
    • HS 1 binding protein antibody
    • HS1 associating protein X 1 antibody
    • HS1 binding protein 1 antibody
    • HS1 binding protein antibody
    • HS1-associating protein X-1 antibody
    • HS1-binding protein 1 antibody
    • HS1BP1 antibody
    • HSP1BP-1 antibody
    • OTTHUMP00000034190 antibody
    • SCN3 antibody
    see all

References for Anti-HAX1 antibody (ab78939)

ab78939 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your inquiry. Here is the alignment for the immunogen for both ab78939 and ab79723 (they are raised against the same peptide):  The isoforms and the percentage of overlap with the immunogen: http://www.uniprot.org/uniprot/Q7TS...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"