Overview

  • Product name
  • Description
    Goat polyclonal to HAX1
  • Specificity
    ab81973 is expected to recognize both reported isoforms (NP_006109.2 and NP_001018238.1).
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    C-TRHEADSSPRGDPES

    , corresponding to internal sequence amino acids 241-255 of human HAX1 according to NP_006109.2 (or 193-207 of NP_001018238.1).

  • Positive control
    • Human kidney, liver and testis lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab81973 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notes
    Peptide ELISA: antibody detection limit dilution 1:2,000.
    WB: Use at a concentration of 1 - 3 µg/ml. Predicted molecular weight: 32 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Promotes cell survival. Potentiates GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. May regulate intracellular calcium pools.
    • Tissue specificity
      Ubiquitous. Up-regulated in oral cancers.
    • Involvement in disease
      Defects in HAX1 are the cause of neutropenia severe congenital autosomal recessive type 3 (SCN3) [MIM:610738]; also known as Kostmann disease. A disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections. Some patients affected by severe congenital neutropenia type 3 have neurological manifestations such as psychomotor retardation and seizures. Note=The clinical phenotype due to HAX1 deficiency appears to depend on the localization of the mutations and their influence on the transcript variants. Mutations affecting exclusively isoform 1 are associated with isolated congenital neutropenia, whereas mutations affecting both isoform 1 and isoform 5 are associated with additional neurologic symptoms.
    • Sequence similarities
      Belongs to the HAX1 family.
    • Post-translational
      modifications
      Proteolytically cleaved by caspase-3 during apoptosis.
    • Cellular localization
      Mitochondrion. Endoplasmic reticulum. Nucleus membrane. Cytoplasmic vesicle. Sarcoplasmic reticulum.
    • Information by UniProt
    • Database links
    • Alternative names
      • FLJ17042 antibody
      • FLJ18492 antibody
      • FLJ93803 antibody
      • HAX 1 antibody
      • HAX-1 antibody
      • HAX1 antibody
      • HAX1_HUMAN antibody
      • Hax1a antibody
      • HCLS1 and PKD2 associated protein antibody
      • HCLS1 associated protein antibody
      • HCLS1 associated protein X 1 antibody
      • HCLS1-associated protein X-1 antibody
      • HCLSBP1 antibody
      • HS 1 associated protein X 1 antibody
      • HS 1 binding protein antibody
      • HS1 associating protein X 1 antibody
      • HS1 binding protein 1 antibody
      • HS1 binding protein antibody
      • HS1-associating protein X-1 antibody
      • HS1-binding protein 1 antibody
      • HS1BP1 antibody
      • HSP1BP-1 antibody
      • OTTHUMP00000034190 antibody
      • SCN3 antibody
      see all

    Images

    • Anti-HAX1 antibody (ab81973) at 1 µg/ml + human testis lysate in RIPA buffer at 35 µg
      Developed using the ECL technique

      Predicted band size : 32 kDa
      Observed band size : 32 kDa


      Exposure time : 1 hour

    References

    ab81973 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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