• Product nameAnti-HAX1 antibody
    See all HAX1 primary antibodies
  • Description
    Rabbit polyclonal to HAX1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Guinea pig, Cow, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 108-157 (PGPESETPGE RLREGQTLRD SMLKYPDSHQ PRIFGGVLES DARSESPQPA) of Human HAX1 (NP_006109).

  • Positive control
    • COLO205 cell lysate.



Our Abpromise guarantee covers the use of ab87185 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 32 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • FunctionPromotes cell survival. Potentiates GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. May regulate intracellular calcium pools.
  • Tissue specificityUbiquitous. Up-regulated in oral cancers.
  • Involvement in diseaseDefects in HAX1 are the cause of neutropenia severe congenital autosomal recessive type 3 (SCN3) [MIM:610738]; also known as Kostmann disease. A disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections. Some patients affected by severe congenital neutropenia type 3 have neurological manifestations such as psychomotor retardation and seizures. Note=The clinical phenotype due to HAX1 deficiency appears to depend on the localization of the mutations and their influence on the transcript variants. Mutations affecting exclusively isoform 1 are associated with isolated congenital neutropenia, whereas mutations affecting both isoform 1 and isoform 5 are associated with additional neurologic symptoms.
  • Sequence similaritiesBelongs to the HAX1 family.
  • Post-translational
    Proteolytically cleaved by caspase-3 during apoptosis.
  • Cellular localizationMitochondrion. Endoplasmic reticulum. Nucleus membrane. Cytoplasmic vesicle. Sarcoplasmic reticulum.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ17042 antibody
    • FLJ18492 antibody
    • FLJ93803 antibody
    • HAX 1 antibody
    • HAX-1 antibody
    • HAX1 antibody
    • HAX1_HUMAN antibody
    • Hax1a antibody
    • HCLS1 and PKD2 associated protein antibody
    • HCLS1 associated protein antibody
    • HCLS1 associated protein X 1 antibody
    • HCLS1-associated protein X-1 antibody
    • HCLSBP1 antibody
    • HS 1 associated protein X 1 antibody
    • HS 1 binding protein antibody
    • HS1 associating protein X 1 antibody
    • HS1 binding protein 1 antibody
    • HS1 binding protein antibody
    • HS1-associating protein X-1 antibody
    • HS1-binding protein 1 antibody
    • HS1BP1 antibody
    • HSP1BP-1 antibody
    • OTTHUMP00000034190 antibody
    • SCN3 antibody
    see all

Anti-HAX1 antibody images

  • Anti-HAX1 antibody (ab87185) at 1 µg/ml (in 5% skim milk / PBS buffer) + COLO205 cell lysate at 10 µg

    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 32 kDa
    Observed band size : 30 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 50 kDa,90 kDa. We are unsure as to the identity of these extra bands.

References for Anti-HAX1 antibody (ab87185)

ab87185 has not yet been referenced specifically in any publications.

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