Anti-hCG receptor antibody (ab125214)

Overview

  • Product nameAnti-hCG receptor antibody
    See all hCG receptor primary antibodies
  • Description
    Rabbit polyclonal to hCG receptor
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide from the N terminal region of Human hCG receptor.

Properties

Applications

Our Abpromise guarantee covers the use of ab125214 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.5 µg/ml. Predicted molecular weight: 79 kDa.

The detection limit for ab125214 is approximately 0.1ng/lane under non-reducing and reducing conditions.

IHC-P Use a concentration of 0.5 - 1 µg/ml.

Target

  • FunctionReceptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
  • Tissue specificityGonadal and thyroid cells.
  • Involvement in diseaseDefects in LHCGR are a cause of familial male precocious puberty (FMPP) [MIM:176410]; also known as testotoxicosis. In FMPP the receptor is constitutively activated.
    Defects in LHCGR are the cause of luteinizing hormone resistance (LHR) [MIM:238320]; also known as Leydig cell hypoplasia in males. LHR is an autosomal recessive disorder characterized by unresponsiveness to luteinizing hormone, defective sexual development in males, and defective follicular development and ovulation, amenorrhea and infertility in females. Two forms of the disorder have been defined in males. Type 1 is a severe form characterized by complete 46,XY male pseudohermaphroditism, low testosterone and high luteinizing hormone levels, total lack of responsiveness to luteinizing and chorionic gonadotropin hormones, lack of breast development, and absent development of secondary male sex characteristics. Type 2, a milder form, displays a broader range of phenotypic expression ranging from micropenis to severe hypospadias.
  • Sequence similaritiesBelongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
    Contains 6 LRR (leucine-rich) repeats.
    Contains 1 LRRNT domain.
  • Cellular localizationCell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Gonadotropin receptor antibody
    • Gpcr19-rs1 antibody
    • GTHR-II antibody
    • HHG antibody
    • LCGR antibody
    • LGR2 antibody
    • LH-R antibody
    • LH/CG R antibody
    • LH/CG-R antibody
    • LH/CGR antibody
    • LHCGR antibody
    • LHR antibody
    • LHRHR antibody
    • LSH R antibody
    • LSH-R antibody
    • LSHR_HUMAN antibody
    • Luteinizing hormone receptor antibody
    • Luteinizing hormone/choriogonadotropin receptor antibody
    • Lutropin choriogonadotropic hormone receptor antibody
    • Lutropin choriogonadotropic receptor antibody
    • Lutropin-choriogonadotropic hormone receptor antibody
    • ULG5 antibody
    see all

References for Anti-hCG receptor antibody (ab125214)

ab125214 has not yet been referenced specifically in any publications.

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This product is tested for rat and Immunohistochemistry in Paraffin sections. We do generally recommend using a heat mediated antigen retrieval step, such as with citrate buffer. This antibody is against Hcg recept...

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We do not generate this antibody in-house and the supplying laboratory considers the immunogen sequence to be proprietary. All we know is that the immunogen is A synthetic peptide corresponding to a sequence at t...

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Thank you very much for your interest in ab125214.

Unfortunately we do not have any IHC images that I can send you at the moment for ab125214. To our knowledge, ab125214 has not been tested in ICC. Therefore, I can offer a discount off a fut...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"