Anti-hCG receptor/LHR antibody (ab125214)
Key features and details
- Rabbit polyclonal to hCG receptor/LHR
- Suitable for: WB, IHC-P
- Reacts with: Rat, Human
- Isotype: IgG
Overview
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Product name
Anti-hCG receptor/LHR antibody
See all hCG receptor/LHR primary antibodies -
Description
Rabbit polyclonal to hCG receptor/LHR -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Rat, Human -
Immunogen
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
Preservatives: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate)
Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Dibasic monohydrogen sodium phosphate -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab125214 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use a concentration of 0.1 - 0.5 µg/ml. Predicted molecular weight: 79 kDa.
The detection limit for ab125214 is approximately 0.1ng/lane under non-reducing and reducing conditions. |
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IHC-P |
Use a concentration of 0.5 - 1 µg/ml.
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Notes |
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WB
Use a concentration of 0.1 - 0.5 µg/ml. Predicted molecular weight: 79 kDa. The detection limit for ab125214 is approximately 0.1ng/lane under non-reducing and reducing conditions. |
IHC-P
Use a concentration of 0.5 - 1 µg/ml. |
Target
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Function
Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. -
Tissue specificity
Gonadal and thyroid cells. -
Involvement in disease
Defects in LHCGR are a cause of familial male precocious puberty (FMPP) [MIM:176410]; also known as testotoxicosis. In FMPP the receptor is constitutively activated.
Defects in LHCGR are the cause of luteinizing hormone resistance (LHR) [MIM:238320]; also known as Leydig cell hypoplasia in males. LHR is an autosomal recessive disorder characterized by unresponsiveness to luteinizing hormone, defective sexual development in males, and defective follicular development and ovulation, amenorrhea and infertility in females. Two forms of the disorder have been defined in males. Type 1 is a severe form characterized by complete 46,XY male pseudohermaphroditism, low testosterone and high luteinizing hormone levels, total lack of responsiveness to luteinizing and chorionic gonadotropin hormones, lack of breast development, and absent development of secondary male sex characteristics. Type 2, a milder form, displays a broader range of phenotypic expression ranging from micropenis to severe hypospadias. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Contains 6 LRR (leucine-rich) repeats.
Contains 1 LRRNT domain. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 3973 Human
- Entrez Gene: 25477 Rat
- Omim: 152790 Human
- SwissProt: P22888 Human
- SwissProt: P16235 Rat
- Unigene: 468490 Human
- Unigene: 11216 Rat
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Alternative names
- Gonadotropin receptor antibody
- Gpcr19-rs1 antibody
- GTHR-II antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab125214 has been referenced in 2 publications.
- Zhang H et al. Seasonal expressions of follicle-stimulating hormone receptor and luteinizing hormone receptor in the scented gland of the male muskrat (Ondatra zibethicus). Am J Physiol Regul Integr Comp Physiol 312:R569-R574 (2017). PubMed: 28228419
- So KH et al. Human chorionic gonadotropin stimulates spheroid attachment on fallopian tube epithelial cells through the mitogen-activated protein kinase pathway and down-regulation of olfactomedin-1. Fertil Steril 104:474-82 (2015). PubMed: 25999259