Overview

  • Product name
    Anti-hCG receptor antibody
    See all hCG receptor primary antibodies
  • Description
    Rabbit polyclonal to hCG receptor
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide, corresponding to a region within the internal sequence amino acids 622-685 of Human hCG receptor.

  • Positive control
    • A431, H1299, HeLa cell lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab96603 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 79 kDa.

Target

  • Function
    Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
  • Tissue specificity
    Gonadal and thyroid cells.
  • Involvement in disease
    Defects in LHCGR are a cause of familial male precocious puberty (FMPP) [MIM:176410]; also known as testotoxicosis. In FMPP the receptor is constitutively activated.
    Defects in LHCGR are the cause of luteinizing hormone resistance (LHR) [MIM:238320]; also known as Leydig cell hypoplasia in males. LHR is an autosomal recessive disorder characterized by unresponsiveness to luteinizing hormone, defective sexual development in males, and defective follicular development and ovulation, amenorrhea and infertility in females. Two forms of the disorder have been defined in males. Type 1 is a severe form characterized by complete 46,XY male pseudohermaphroditism, low testosterone and high luteinizing hormone levels, total lack of responsiveness to luteinizing and chorionic gonadotropin hormones, lack of breast development, and absent development of secondary male sex characteristics. Type 2, a milder form, displays a broader range of phenotypic expression ranging from micropenis to severe hypospadias.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
    Contains 6 LRR (leucine-rich) repeats.
    Contains 1 LRRNT domain.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Gonadotropin receptor antibody
    • Gpcr19-rs1 antibody
    • GTHR-II antibody
    • HHG antibody
    • LCGR antibody
    • LGR2 antibody
    • LH-R antibody
    • LH/CG R antibody
    • LH/CG-R antibody
    • LH/CGR antibody
    • LHCGR antibody
    • LHR antibody
    • LHRHR antibody
    • LSH R antibody
    • LSH-R antibody
    • LSHR_HUMAN antibody
    • Luteinizing hormone receptor antibody
    • Luteinizing hormone/choriogonadotropin receptor antibody
    • Lutropin choriogonadotropic hormone receptor antibody
    • Lutropin choriogonadotropic receptor antibody
    • Lutropin-choriogonadotropic hormone receptor antibody
    • ULG5 antibody
    see all

Anti-hCG receptor antibody images

  • Anti-hCG receptor antibody (ab96603) at 1/1000 dilution + H1299 whole cell lysate at 30 µg

    Predicted band size : 79 kDa

References for Anti-hCG receptor antibody (ab96603)

This product has been referenced in:
  • Yu L  et al. MFGE8 regulates TGF-ß-induced epithelial mesenchymal transition in endometrial epithelial cells in vitro. Reproduction 152:225-33 (2016). ICC/IF ; Human . Read more (PubMed: 27340235) »

See 1 Publication for this product

Product Wall

Thank you for confirming these details and for your cooperation. The details provided enable us to closely monitor the quality of our products. I have issued a free of charge control lysate (ab30257) as goodwill with the order number. To check th...

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Thank you for taking the time to look into this and for your response.

We have not tested this in HepG2 cells and the positive control recommendations were based on the literature. I thank you for your recommendation with this and have remov...

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Thank you for contacting us. I was able to find the reference that you spoke of on the phone (ShanLX, HardyMP Endocrinology.1992 Sep;131(3):1107-14. (PMID:1505454,http://www.ncbi.nlm.nih.gov/pubmed/1505454). During my research for this question ...

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