General notesab94153 is a 293T cell transfected lysate in which Human HCLS1 has been transiently over-expressed using a pCMV-HCLS1 plasmid. The lysate is provided in 1X Sample Buffer.
Note: For more details about how the transfected lysate was prepared view preparation notes
BackgroundDevelopmental stage: Expressed in early stage of myeloid and erythroid differentiation.
Function: Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
PTM: Phosphorylated by LYN; rapidly after cross-linking of surface IgM on B-cells.
Similarity: Contains 4 cortactin repeats.
Contains 1 SH3 domain.
Tissue specificity: Expressed only in tissues and cells of hematopoietic origin.