Overview

  • Product name
  • Description
    Goat polyclonal to HCN3
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Rat
    Predicted to work with: Cow, Human
  • Immunogen

    Synthetic peptide:

    C-RGVRGRAPSTGAQ

    , corresponding to internal sequence amino acids 583-595 of Human HCN3 (NP_065948.1).

  • Positive control
    • Rat kidney lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab109807 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 85 kDa (predicted molecular weight: 86 kDa).

Target

  • Function
    Putative hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions.
  • Sequence similarities
    Belongs to the potassium channel HCN family.
    Contains 1 cyclic nucleotide-binding domain.
  • Domain
    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Hcn3 antibody
    • HCN3_HUMAN antibody
    • hyperpolarization activated cyclic nucleotide-gated potassium channel 3 antibody
    • KIAA1535 antibody
    • Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 antibody
    see all

Images

  • Anti-HCN3 antibody (ab109807) at 1 µg/ml + Rat kidney lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 86 kDa
    Observed band size : 85 kDa (why is the actual band size different from the predicted?)


    Exposure time : 1 hour

References

This product has been referenced in:
  • Kretschmannova K  et al. The expression and role of hyperpolarization-activated and cyclic nucleotide-gated channels in endocrine anterior pituitary cells. Mol Endocrinol 26:153-64 (2012). WB ; Rat . Read more (PubMed: 22135067) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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