• Product name
  • Description
    Goat polyclonal to HCP1
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide derived from Human HCP1.

  • Positive control
    • Human placenta tissue.



Our Abpromise guarantee covers the use of ab112004 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.


  • Function
    Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme.
  • Tissue specificity
    Expressed in kidney, liver, placenta, small intestine, spleen, retina and retinal pigment epithelium. Lower levels found in colon and testis. Very low levels in brain, lung, stomach, heart and muscle. In intestine, expressed in duodenum with lower levels in jejunum, ileum, cecum, rectum and segments of the colon.
  • Involvement in disease
    Defects in SLC46A1 are the cause of hereditary folate malabsorption (HFM) [MIM:229050]. HFM is a rare autosomal recessive disorder characterized by impaired intestinal folate absorption with folate deficiency resulting in anemia, hypoimmunoglobulinemia with recurrent infections, and recurrent or chronic diarrhea. In many patients, neurological abnormalities such as seizures or mental retardation become apparent during early childhood, attributed to impaired transport of folates into the central nervous system. When diagnosed early, the disorder can be treated by administration of folate. If untreated, it can be fatal and, if treatment is delayed, the neurological defects can become permanent.
  • Sequence similarities
    Belongs to the major facilitator superfamily. SLC46A family.
  • Cellular localization
    Apical cell membrane. Cytoplasm. Localizes to the apical membrane of intestinal cells in iron-deficient cells, while it resides in the cytoplasm in iron-replete cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • G21 antibody
    • HCP 1 antibody
    • Heme carrier protein 1 antibody
    • MGC9564 antibody
    • PCFT antibody
    • PCFT/HCP1 antibody
    • PCFT_HUMAN antibody
    • PDE7A antibody
    • Proton coupled folate transporter antibody
    • Proton-coupled folate transporter antibody
    • SLC46A1 antibody
    • Solute carrier family 46 (folate transporter) member 1 antibody
    • Solute carrier family 46 member 1 antibody
    see all


  • ab112004, at 3.75µg/ml, staining HCP1 in formalin-fixed, paraffin-embedded Human Placenta tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.


ab112004 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab112004.
Please use the links above to contact us or submit feedback about this product.


Sign up