Overview

  • Product name
  • Description
    Rabbit polyclonal to HDAC10
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide, corresponding to amino acids near the N terminus of Human HDAC10.

  • Positive control
    • Jurkat Cells, Mouse Intestine and Rat Brain for Western blot.

Properties

Applications

Our Abpromise guarantee covers the use of ab18971 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    WB: Use at a concentration of 1 - 4 µg/ml. Detects a band of approximately 74 kDa (predicted molecular weight: 71 kDa). A 55 kDa band can also be detected in mouse and rat tissue lysate.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
    • Tissue specificity
      Ubiquitous. High expression in liver, spleen, pancreas and kidney.
    • Sequence similarities
      Belongs to the histone deacetylase family. HD type 2 subfamily.
    • Cellular localization
      Cytoplasm. Nucleus. Excluded from the nucleoli.
    • Information by UniProt
    • Database links
    • Alternative names
      • DKFZP761B039 antibody
      • HD 10 antibody
      • HD10 antibody
      • HDA10_HUMAN antibody
      • HDAC 10 antibody
      • Hdac10 antibody
      • Histone deacetylase 10 antibody
      • MGC149722 antibody
      • OTTHUMP00000028555 antibody
      see all

    Anti-HDAC10 antibody images

    • All lanes : Anti-HDAC10 antibody (ab18971) at 2.5 µg/ml

      Lane 1 : Jurkat cell lysate (30ug)
      Lane 2 : Mouse intestine lysate (30ug)
      Lane 3 : Rat brain lysate (30ug)


      Predicted band size : 71 kDa
      Observed band size : 74 kDa (why is the actual band size different from the predicted?)
      Additional bands at : 55 kDa. We are unsure as to the identity of these extra bands.

    References for Anti-HDAC10 antibody (ab18971)

    This product has been referenced in:
    • Liu J  et al. Both HDAC5 and HDAC6 are required for the proliferation and metastasis of melanoma cells. J Transl Med 14:7 (2016). Human . Read more (PubMed: 26747087) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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