Overview

  • Product name
    Anti-HDAC10 antibody [EPR3576]
    See all HDAC10 primary antibodies
  • Description
    Rabbit monoclonal [EPR3576] to HDAC10
  • Tested applications
    Suitable for: WB, IP, ICCmore details
    Unsuitable for: Flow Cyt or IHC-P
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    A synthetic peptide corresponding to residues in Human HDAC10

  • Positive control
    • HeLa, 293T, Jurkat, HepG2, A673 and NIH/3T3 cell lysates
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Properties

Applications

Our Abpromise guarantee covers the use of ab108934 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 75 kDa.
IP 1/10 - 1/100.
ICC 1/100 - 1/250.
  • Application notes
    Is unsuitable for Flow Cyt or IHC-P.
  • Target

    • Function
      Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
    • Tissue specificity
      Ubiquitous. High expression in liver, spleen, pancreas and kidney.
    • Sequence similarities
      Belongs to the histone deacetylase family. HD type 2 subfamily.
    • Cellular localization
      Cytoplasm. Nucleus. Excluded from the nucleoli.
    • Information by UniProt
    • Database links
    • Alternative names
      • DKFZP761B039 antibody
      • HD 10 antibody
      • HD10 antibody
      • HDA10_HUMAN antibody
      • HDAC 10 antibody
      • Hdac10 antibody
      • Histone deacetylase 10 antibody
      • MGC149722 antibody
      • OTTHUMP00000028555 antibody
      see all

    Images

    • All lanes : Anti-HDAC10 antibody [EPR3576] (ab108934) at 1/1000 dilution

      Lane 1 : HeLa cell lysate
      Lane 2 : 293T cell lysate
      Lane 3 : Jurkat cell lysate
      Lane 4 : HepG2 cell lysate
      Lane 5 : A673 cell lysate
      Lane 6 : NIH/3T3 cell lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 75 kDa

    References

    This product has been referenced in:
    • Mondello P  et al. Panobinostat acts synergistically with ibrutinib in diffuse large B cell lymphoma cells with MyD88 L265 mutations. JCI Insight 2:e90196 (2017). WB ; Human . Read more (PubMed: 28352655) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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