FunctionResponsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Tissue specificityUbiquitous. High expression in liver, spleen, pancreas and kidney.
Sequence similaritiesBelongs to the histone deacetylase family. HD type 2 subfamily.
Cellular localizationCytoplasm. Nucleus. Excluded from the nucleoli.