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Overview

  • Product nameHDAC3 protein (Tagged)See all HDAC3 proteins and peptides ...
  • Protein descriptionRecombinant full length human HDAC3 isolated from Baculovirus with Flag tag, amino acids 1-428. Swiss ID = O15379.
  • Expression hostBaculovirus

    • Properties

  • Purity> 95 % by SDS-PAGE
  • Biological activity1 unit equals 1 nanogram of purified protein.
  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 20% Glycerol, 20mM Tris Cl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab82071 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE
  • Application notesSDS-PAGE: Use at an assay dependent dilution.
    in vitro function studies (including transcription in the presence of co-factors suchas N-CoR): Use at an assay dependent dilution.
    Protein-protein interaction assay: Use at an assay dependent dilution.
    Cell growth assay: Use at an assay dependent dilution.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        HD3HDAC 3HDAC3
        HDAC3_HUMANhistone deacetylase 3RPD3RPD3 2RPD3-2SMAP45
      see all
  • FunctionResponsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.
  • Tissue specificityWidely expressed.
  • Sequence similaritiesBelongs to the histone deacetylase family. HD type 1 subfamily.
  • Post-translational
    modifications    Sumoylated in vitro.
  • Cellular localizationNucleus.

    • Target information above from: UniProt accession O15379 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    HDAC3 protein (Tagged) images

    References for HDAC3 protein (Tagged) (ab82071)

    ab82071 has not yet been referenced specifically in any publications.

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