Overview

  • Product nameAnti-HEAB antibody
    See all HEAB primary antibodies
  • Description
    Mouse monoclonal to HEAB
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 316-426 of Human HEAB

Properties

Applications

Our Abpromise guarantee covers the use of ab56878 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionPolynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.
    • Sequence similaritiesBelongs to the Clp1 family. Clp1 subfamily.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • ATP/GTP binding protein antibody
      • Cleavage and polyadenylation factor I subunit 1 antibody
      • CLP 1 antibody
      • clp1 antibody
      • CLP1 cleavage and polyadenylation factor I subunit homolog antibody
      • CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae) antibody
      • CLP1, yeast, homolog of antibody
      • CLP1_HUMAN antibody
      • hClp1 antibody
      • Homolog of yeast CFIA subunit Clp1p antibody
      • Polyadenylation factor Clp1 antibody
      • Polynucleotide kinase Clp1 antibody
      • Polyribonucleotide 5' hydroxyl kinase Clp1 antibody
      • Polyribonucleotide 5''-hydroxyl-kinase Clp1 antibody
      • Pre mRNA cleavage complex II protein Clp1 antibody
      • Pre-mRNA cleavage complex II protein Clp1 antibody
      see all

    Anti-HEAB antibody images

    • Western blot against tagged recombinant protein immunogen using ab56878 HEAB antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa

    References for Anti-HEAB antibody (ab56878)

    ab56878 has not yet been referenced specifically in any publications.

    Product Wall

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"