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Read our guarantee »Products:Signal Transduction >> Cytoskeleton / ECM >> Cytoskeleton >> Motor Proteins >> Myosin
Anti-heavy chain Myosin antibody [WB-MHCs]
See all heavy chain Myosin products (5) ...
Mouse monoclonal [WB-MHCs] to heavy chain Myosin
This antibody is specific to heavy chain Myosin (myosin slow type heavy chain).
IHC-Frmore details
Reacts with
Mouse, Rat, Sheep, Rabbit, Goat, Dog, Human, Pig
Native myosin extracted from rabbit soleus muscle.
Immunohistochemistry: Type I myosin heavy chain in human, rat, mouse, rabbit, dog, sheep, pig and goat muscle.
Liquid
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: 15mM Sodium Azide
Constituents: Tissue culture supernatant
Tissue culture supernatant
Monoclonal
WB-MHCs
P3-NS1/1-Ag4-1
IgG1
Signal Transduction >> Cytoskeleton / ECM >> Cytoskeleton >> Motor Proteins >> Myosin
Our Abpromise guarantee covers the use of ab49463 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-Fr (unfixed): 1/20 - 1/80.
Is unsuitable for IHC-P or WB.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Muscle contraction.
Defects in MYH3 are the cause of distal arthrogryposis type 2A (DA2A) [MIM:193700]; also known as Freeman-Sheldon syndrome (FSS). Distal arthrogryposis is a clinically and genetically heterogeneous group of disorders characterized by bone anomalies and joint contractures of the hands and feet, causing medially overlapping fingers, clenched fists, ulnar deviation of fingers, camptodactyly and positional foot deformities. It is a disorder of primary limb malformation without primary neurologic or muscle disease. DA2A is the most severe form of distal arthrogryposis. Affected individuals have contractures of the orofacial muscles, characterized by microstomia with pouting lips, H-shaped dimpling of the chin, deep nasolabial folds, and blepharophimosis. Dysphagia, failure to thrive, growth deficit, and life-threatening respiratory complications (caused by structural anomalies of the oropharynx and upper airways) are frequent. Inheritance is autosomal dominant.
Defects in MYH3 are the cause of distal arthrogryposis type 2B (DA2B) [MIM:601680]; also known as Sheldon-Hall syndrome (SHS) or arthrogryposis multiplex congenita distal type 2B (AMCD2B). DA2B is a form of inherited multiple congenital contractures. Affected individuals have vertical talus, ulnar deviation in the hands, severe camptodactyly, and a distinctive face characterized by a triangular shape, prominent nasolabial folds, small mouth and a prominent chin. DA2B is the most common of the distal arthrogryposis syndromes. It is similar to DA2A but the facial contractures are less dramatic.
Contains 1 IQ domain.
Contains 1 myosin head-like domain.
Abundantly present in fetal skeletal muscle and not present or barely detectable in heart and adult skeletal muscle.
The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
Cytoplasm > myofibril. Thick filaments of the myofibrils.
Target information above from: UniProt accessionP11055
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
ab49463 has not yet been referenced specifically in any publications.
Publishing research using ab49463? Please let us know so that we can cite the reference in this datasheet
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