Overview

  • Product nameAnti-Helicobacter pylori CagA antibody [B818M]
  • Description
    Mouse monoclonal [B818M] to Helicobacter pylori CagA
  • Tested applicationsSuitable for: WB, ELISA, Sandwich ELISAmore details
  • Species reactivity
    Reacts with
  • Immunogen

    Recombinant fragments of CA gene of Helicobacter pylori.

  • Epitopeab90490 recognizes an epitope localized between Asp562 and Gln795 in the GenBank FJ428215 amino acid sequence.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage bufferPreservative: 0.1% Sodium Azide
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • PurityProtein G purified
  • Purification notesab90490 is purified from ascites by Protein G chromatography and is >95% pure as assessed by SDS-PAGE.
  • ClonalityMonoclonal
  • Clone numberB818M
  • MyelomaSp2/0
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab90490 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 124 kDa.
ELISA Use at an assay dependent concentration.
Sandwich ELISA Use at an assay dependent concentration. This antibody has been tested as the capture antibody, while the recommended pair was used as detection antibody.

Target

  • RelevanceIt is known that H. pylori strains exhibit a significant degree of diversity. The great variability in the H. pylori genome may explain why not all infected individuals suffer from ulcer. Some H. pylori strains contain particular pathogenic genes such as cytokine associated gene A (CagA), while others lack these genes. The CagA protein of H. pylori has been found to be associated with more severe clinical manifestations, such as ulcer disease and gastric cancer. Thus, discrimination between potentially virulent strains may be relevant.
  • Alternative names
    • 120 kDa protein antibody
    • CAG pathogenicity island protein 26 antibody
    • cag26 antibody
    • cagA antibody
    • cai antibody
    • Cytotoxicity-associated immunodominant antigen antibody
    • H. pylori CagA antibody
    • H. pylori cytokine associated gene A antibody
    • Helicobacter pylori cytokine associated gene A antibody
    see all

References for Anti-Helicobacter pylori CagA antibody [B818M] (ab90490)

This product has been referenced in:
  • McCracken KW  et al. Modelling human development and disease in pluripotent stem-cell-derived gastric organoids. Nature 516:400-4 (2014). Read more (PubMed: 25363776) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"