Anti-Hemoglobin A1c antibody [8.F.127A] (ab33847)

Overview

  • Product nameAnti-Hemoglobin A1c antibody [8.F.127A]
    See all Hemoglobin A1c primary antibodies
  • Description
    Mouse monoclonal [8.F.127A] to Hemoglobin A1c
  • SpecificityThe antibody recognizes human Hemoglobin A1c (the diabetic glycated hemoglobin marker),and all variants of A1c and S1c (the sickle cell glycated hemoglobin marker).
  • Tested applicationsSuitable for: ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Hemoglobin A1c, N-terminal of the beta chain

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Add glycerol to a final volume of 50% for extra stability and aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage bufferPreservative: 0.05% Sodium Azide
    Constituents: Tris buffered saline, pH 7.2
  • Concentration information loading...
  • PurityProtein A purified
  • ClonalityMonoclonal
  • Clone number8.F.127A
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab33847 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.

Target

  • FunctionInvolved in oxygen transport from the lung to the various peripheral tissues.
    LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.
    Spinorphin: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation.
  • Tissue specificityRed blood cells.
  • Involvement in diseaseHeinz body anemias
    Beta-thalassemia
    Sickle cell anemia
    Beta-thalassemia, dominant, inclusion body type
  • Sequence similaritiesBelongs to the globin family.
  • Post-translational
    modifications
    Glucose reacts non-enzymatically with the N-terminus of the beta chain to form a stable ketoamine linkage. This takes place slowly and continuously throughout the 120-day life span of the red blood cell. The rate of glycation is increased in patients with diabetes mellitus.
    S-nitrosylated; a nitric oxide group is first bound to Fe(2+) and then transferred to Cys-94 to allow capture of O(2).
    Acetylated on Lys-60, Lys-83 and Lys-145 upon aspirin exposure. PubMed:16916647 reports the identification of HBB acetylated on Lys-145 in the cytosolic fraction of HeLa cells. This may have resulted from contamination of the sample.
  • Information by UniProt
  • Database links
  • Alternative names
    • Beta-globin antibody
    • HBB antibody
    • HBB_HUMAN antibody
    • Hemoglobin beta chain antibody
    • Spinorphin antibody
    see all

References for Anti-Hemoglobin A1c antibody [8.F.127A] (ab33847)

ab33847 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiries. Ab33847: This Ab is specific for Human hemoglobin A1C (the diabetic glycated hemoglobin marker); and also recognizes hemoglobin S1C (the sickle cell glycated hemoglobin marker). It does not recognize hemoglobin A. ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"