Overview

  • Product nameAnti-Heparin Cofactor II antibody [74E5]
    See all Heparin Cofactor II primary antibodies
  • Description
    Mouse monoclonal [74E5] to Heparin Cofactor II
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length native Heparin Cofactor II (purified) from Human plasma

  • Positive control
    • Human plasma

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • Storage bufferPreservative: None
    Constituents: 50% Glycerol, PBS
  • Concentration information loading...
  • ClonalityMonoclonal
  • Clone number74E5
  • IsotypeIgG2b
  • Light chain typekappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab51051 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000. Predicted molecular weight: 57 kDa.
ELISA Use at an assay dependent dilution.

Target

  • FunctionThrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
    Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.
  • Tissue specificityExpressed predominantly in liver. Also present in plasma.
  • Involvement in diseaseThrombophilia due to heparin cofactor 2 deficiency
  • Sequence similaritiesBelongs to the serpin family.
  • DomainThe N-terminal acidic repeat region mediates, in part, the glycosaminoglycan-accelerated thrombin inhibition.
  • Post-translational
    modifications
    Phosphorylation sites are present in the extracellular medium.
  • Information by UniProt
  • Database links
  • Alternative names
    • D22S673 antibody
    • HC II antibody
    • HC-II antibody
    • HC2 antibody
    • HCF2 antibody
    • HEP2_HUMAN antibody
    • Heparin cofactor 2 antibody
    • Heparin cofactor II antibody
    • HLS2 antibody
    • Leuserpin 2 antibody
    • LS2 antibody
    • Protease inhibitor leuserpin 2 antibody
    • Protease inhibitor leuserpin-2 antibody
    • serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1 antibody
    • Serpin D1 antibody
    • serpin peptidase inhibitor, clade D (heparin cofactor), member 1 antibody
    • SERPIND1 antibody
    • THPH10 antibody
    see all

Anti-Heparin Cofactor II antibody [74E5] images

  • All lanes : Anti-Heparin Cofactor II antibody [74E5] (ab51051) at 1/2000 dilution

    Lane 1 : Heparin Cofactor II isolated from human plasma
    Lane 2 : Human plasma


    Predicted band size : 57 kDa
    Observed band size : 70 kDa (why is the actual band size different from the predicted?)

References for Anti-Heparin Cofactor II antibody [74E5] (ab51051)

This product has been referenced in:
  • Acosta-Martin AE  et al. Quantitative mass spectrometry analysis using PAcIFIC for the identification of plasma diagnostic biomarkers for abdominal aortic aneurysm. PLoS One 6:e28698 (2011). WB ; Human . Read more (PubMed: 22163325) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"