Anti-Heparin Cofactor II antibody (ab31661)

Overview

  • Product name
    Anti-Heparin Cofactor II antibody
    See all Heparin Cofactor II primary antibodies
  • Description
    Goat polyclonal to Heparin Cofactor II
  • Specificity
    This antibody recognizes Heparin Cofactor II
  • Tested applications
    Suitable for: ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Heparin Cofactor II.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer
    Preservative: None
    Constituents: 50% Glycerol, 0.1M Sodium chloride, 0.01M HEPES. pH 6.5
  • Concentration information loading...
  • Purity
    IgG fraction
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab31661 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.

Target

  • Function
    Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
    Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.
  • Tissue specificity
    Expressed predominantly in liver. Also present in plasma.
  • Involvement in disease
    Thrombophilia due to heparin cofactor 2 deficiency
  • Sequence similarities
    Belongs to the serpin family.
  • Domain
    The N-terminal acidic repeat region mediates, in part, the glycosaminoglycan-accelerated thrombin inhibition.
  • Post-translational
    modifications
    Phosphorylation sites are present in the extracellular medium.
  • Information by UniProt
  • Database links
  • Alternative names
    • D22S673 antibody
    • HC II antibody
    • HC-II antibody
    • HC2 antibody
    • HCF2 antibody
    • HEP2_HUMAN antibody
    • Heparin cofactor 2 antibody
    • Heparin cofactor II antibody
    • HLS2 antibody
    • Leuserpin 2 antibody
    • LS2 antibody
    • Protease inhibitor leuserpin 2 antibody
    • Protease inhibitor leuserpin-2 antibody
    • serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1 antibody
    • Serpin D1 antibody
    • serpin peptidase inhibitor, clade D (heparin cofactor), member 1 antibody
    • SERPIND1 antibody
    • THPH10 antibody
    see all

References

ab31661 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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