Hepatitis B Virus Core Antigen protein fragment (ab49014)

Overview

Description

  • NatureRecombinant
  • SourceE. coli
  • Amino Acid Sequence
    • Amino acids1 to 144
    • Additional sequence informationDeleted DNA binding domain. Fully competent for self-assembly.

Specifications

Our Abpromise guarantee covers the use of ab49014 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityReacts strongly with human HBV positive serum.
  • Applications

    Western blot

    ELISA

  • Purity> 95 % by SDS-PAGE.

  • FormLiquid
  • Additional Notes


    During infection, the C gene of HBV often displays genetic deletions within the tip of the protruding spikes of HBcAg, which are known to contain the major site for antibody binding . These have been referred to as core internal deletion variants, and they often appear in end stage liver disease. Depending on the nature of the deletion, they may still form functional capsids,

    Reacts strongly with human HBV positive serum.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 75mM Sodium chloride, 7.5mM PBS, pH 7.2

General info

  • Alternative names
    • C
    • Capsid protein
    • Core and e antigen
    • Core antigen
    • Core protein
    • HBc
    • HBcAg
    • HBVgp4
    • Hepatitis B Virus core antigen
    • p21.5
    • precore/core protein
    see all
  • RelevanceHepatitis B Virus Core Antigen (HBcAg) is part of the infectious virion containing an inner "core particle" enclosing the viral genome. The icosahedral core particle contains 180 or 240 copies of the core protein. HBcAg is one of the three major clinical antigens of hepatitis B virus but disappears early in the course of infection. The hepatitis B virus core antigen (HBcAg) is a highly immunogenic subviral particle and functions as both a T-cell-dependent and a T-cell-independent antigen. Therefore, HBcAg may be a promising candidate target for therapeutic vaccine control of chronic HBV infection.
  • Cellular localizationCapsid protein: Virion. Host cytoplasm, hepatocyte nucleus.

References for Hepatitis B Virus Core Antigen protein fragment (ab49014)

ab49014 has not yet been referenced specifically in any publications.

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