Anti-Hepatitis B Virus pre S2 Antigen antibody [S9] (ab65406)

Overview

  • Product name
    Anti-Hepatitis B Virus pre S2 Antigen antibody [S9]
    See all Hepatitis B Virus pre S2 Antigen primary antibodies
  • Description
    Mouse monoclonal [S9] to Hepatitis B Virus pre S2 Antigen
  • Specificity
    Reacts strongly with WHc but not DHBc in ELISA and Western blot. Also reacts with synthetic HBc peptides.
  • Tested applications
    Suitable for: IHC-P, IHC-Fr, WB, ELISA, ICC/IFmore details
  • Species reactivity
    Reacts with: Hepatitis B virus
  • Immunogen

    Recombinant full length HBcAg (ayw type)

  • Epitope
    amino acids 130-138 of preS2

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.01% Sodium Azide
    Constituents: 10mM PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Monoclonal
  • Clone number
    S9
  • Isotype
    IgG1
  • Light chain type
    kappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab65406 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Predicted molecular weight: 31 kDa.
ELISA Use at an assay dependent concentration.
ICC/IF Use at an assay dependent concentration.

Target

  • Relevance
    The human hepatitis B virus (HBV) is a DNA virus that causes chronic infections that frequently lead to the development of cirrhosis and cellular hepatocellular carcinoma. The HBsAg (surface antigen) gene is one long open reading frame but contains three in frame "start" (ATG) codons that divide the gene into three sections, pre-S1, pre-S2, and S. Because of the multiple start codons, polypeptides of three different sizes called large, middle, and small (pre-S1 + pre-S2 + S, pre-S2 + S, or S) are produced. The preS2 domain is the minimal functional unit of transcription activators that are encoded by the Hepatitis B virus (HBV) surface (S) gene. It is present in more than one-third of the HBV-integrates in HBV induced hepatocarcinoma (HCC). Pre-S2 is a diagnostically important surface antigen of human hepatitis B virus. The PreS domain (S1 + S2) of Hepatitis B virus (HBV) surface antigen may be a good candidate for an effective vaccine as it activates both B and T cells besides binding to hepatocytes.
  • Cellular localization
    Virion membrane (By similarity).
  • Database links
    • Alternative names
      • HBV pre S2 Antigen antibody
      • HBV pre S2 protein antibody
      • Hepatitis B Virus pre S2 protein antibody
      • PreS2/S antigen antibody
      • S antibody
      see all

    References

    ab65406 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    Thank you for contacting us. The epitope recognized by ab65406 has been mapped to amino acids 130-138 of HBV preS2: MCLRRFIIF. I hope this helps, please let me know if you need any additional information.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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