Anti-Hepatitis B Virus Surface Antigen ad + ay antibody [HB24] (ab54247)

Overview

  • Product name
    Anti-Hepatitis B Virus Surface Antigen ad + ay antibody [HB24]
  • Description
    Mouse monoclonal [HB24] to Hepatitis B Virus Surface Antigen ad + ay
  • Specificity
    ab54247 recognises a common epitope of the plasma HBsAg of ad and ay subtypes.
  • Tested applications
    Suitable for: ELISAmore details
  • Species reactivity
    Reacts with: Hepatitis B virus
  • Immunogen

    Full length native protein (purified) (Hepatitis B virus)

  • General notes
    Affinity 1.4 x 10-9 M (ad) 2.0 x 10-9 M (ay)

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.1% Sodium Azide
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Monoclonal
  • Clone number
    HB24
  • Isotype
    IgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab54247 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.

Target

  • Relevance
    Hepatitis B Virus (HBV) infection induces a disease state characterised by liver damage, inflammation and viral persistence. Infection also increases the risk of hepatocellular carcinoma. HBV belongs to the Hepadnaviridae family of viruses. Its genome consists of partially double stranded circular DNA. The DNA is enclosed in a nucleocapsid, or core antigen (HBcAg), which is surrounded by a spherical envelope (surface antigen or HBsAg). The core antigen shares its sequences with the e antigen (HBeAg) but no cross reactivity between the two proteins has been observed. The HBV genome also encodes a DNA polymerase that also acts as a reverse transcriptase. Hepatitis B infection is normally diagnosed from serological tests that detect HBsAg but as the disease progresses this antigen may no longer be present in the blood and tests for HBcAg are used. If HBsAg can be detected in the blood for longer than six months, chronic hepatitis B is diagnosed. The antigenic determinant of the protein moiety of the HBsAg determines specific characteristics of different serotypes and provides the basis of immunodetection. HBsAg has antigenic heterogeneity, specifically, two pairs of sub specific determinants, d/y and w/r allow the following combinations: adw, ayw, adr, ayr.
  • Cellular localization
    Secreted
  • Database links
    • Alternative names
      • HBsAg antibody
      • HBV major surface antigen antibody
      • HBV surface antigen antibody
      • Hepatitis B Virus major surface antigen antibody
      • Major surface antigen antibody
      • S antibody
      see all

    References

    ab54247 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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