Anti-Hepatitis B Virus Surface Antigen antibody (FITC) (ab21021)

Overview

  • Product nameAnti-Hepatitis B Virus Surface Antigen antibody (FITC)
    See all Hepatitis B Virus Surface Antigen primary antibodies
  • Description
    Rabbit polyclonal to Hepatitis B Virus Surface Antigen (FITC)
  • ConjugationFITC. Ex: 493nm, Em: 528nm
  • SpecificityMonospecific, reacts only with Hepatitis B surface antigen including the pre-S1 epitope. This product is non-reactive with normal human serum.
  • Tested applicationsSuitable for: ICC/IFmore details
  • Immunogen

    Hepatitis B surface antigen purified from human serum. Mixture of subtypes ad & ay.

  • General notes

    Covalently coupled with high purity Isomer I of fluorescein isothiocyanate. Care is taken to ensure complete removal of any free fluorescein from the final product.

Properties

Applications

Our Abpromise guarantee covers the use of ab21021 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF
  • Application notesDirect FA staining: Use at an assay dependent dilution. A starting range of 1:10-1:50 is suggested. Acetone fixation of the antigen source is recommended prior to staining.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceHepatitis B Virus (HBV) infection induces a disease state which manifests itself in a variety of ways, characterized by the extent of liver damage, inflammation and viral persistence. HBV infection is also associated with a 100 fold increased risk of hepatocellular carcinoma and currently infects over 250 million people worldwide. HBV has a partially double stranded 3.2 kilobase DNA genome which contains four open reading frames. One of these encodes a 154 amino acid protein called the HBx protein. HBx has been shown to be a transcriptional transactivator of both viral and cellular promoters. Lacking a DNA binding domain and nuclear localization signal, HBx is believed to exert transcriptional activity through protein protein interaction.
    • Cellular localizationVirion membrane
    • Alternative names
      • Large envelope protein antibody
      • Large surface protein antibody
      • LHB antibody
      • Major surface antigen antibody

    References for Anti-Hepatitis B Virus Surface Antigen antibody (FITC) (ab21021)

    ab21021 has not yet been referenced specifically in any publications.

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