Anti-Hepatitis B Virus Surface Antigen (Ayw) antibody [HB5] (ab20724)

Overview

  • Product name
    Anti-Hepatitis B Virus Surface Antigen (Ayw) antibody [HB5]
  • Description
    Mouse monoclonal [HB5] to Hepatitis B Virus Surface Antigen (Ayw)
  • Specificity
    Hepatitis B virus surface antigen. Reacts with the following HBsAg subtypes: ayw1, ayw2, ayw3, ayw4, ayr, adw2, adw4, adrq+, adrq-, ayw3 (Fer).
  • Tested applications
    Suitable for: ELISAmore details
  • Immunogen

    Recombinant HBsAg of ayw subtype.

  • General notes

    Abcam is committed to meeting high standards of ethical manufacturing and as such, we will be discontinuing this product, which has been generated by the ascites method, within the next year. We are sorry for any inconvenience this may cause. If you would like help finding an alternative product, please do not hesitate to contact our scientific support team.

Properties

Applications

Our Abpromise guarantee covers the use of ab20724 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
  • Application notes
    ELISA: Detection of HBsAg in two-site enzyme immunoassay. Use at an assay dependent dilution.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Relevance
      Hepatitis B Virus (HBV) infection induces a disease state characterised by liver damage, inflammation and viral persistence. Infection also increases the risk of hepatocellular carcinoma. HBV belongs to the Hepadnaviridae family of viruses. Its genome consists of partially double stranded circular DNA. The DNA is enclosed in a nucleocapsid, or core antigen (HBcAg), which is surrounded by a spherical envelope (surface antigen or HBsAg). The core antigen shares its sequences with the e antigen (HBeAg) but no cross reactivity between the two proteins has been observed. The HBV genome also encodes a DNA polymerase that also acts as a reverse transcriptase. Hepatitis B infection is normally diagnosed from serological tests that detect HBsAg but as the disease progresses this antigen may no longer be present in the blood and tests for HBcAg are used. If HBsAg can be detected in the blood for longer than six months, chronic hepatitis B is diagnosed. The antigenic determinant of the protein moiety of the HBsAg determines specific characteristics of different serotypes and provides the basis of immunodetection. HBsAg has antigenic heterogeneity, specifically, two pairs of sub specific determinants, d/y and w/r allow the following combinations: adw, ayw, adr, ayr.
    • Cellular localization
      Cytoplasmic
    • Alternative names
      • HBsAg antibody

    References

    ab20724 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    Thank you for your email.
    We do offer a variety of antibodies that will recognize the four major serotypes: adr, adw, ayr, ayw.
    If it has been tested which serotype is recognizwed by an antibody this information can be found on the datasheet ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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