Anti-Hepatitis C Virus Core Antigen antibody [1E5] (ab2582)

Overview

  • Product nameAnti-Hepatitis C Virus Core Antigen antibody [1E5]
    See all Hepatitis C Virus Core Antigen primary antibodies
  • Description
    Mouse monoclonal [1E5] to Hepatitis C Virus Core Antigen
  • SpecificityThis antibody is specific for Hepatitis C Core Antigen.
  • Tested applicationsSuitable for: ELISA, IPmore details
  • Immunogen

    Recombinant fragment, corresponding to amino acids 2-80 of Hepatitis C Virus Core Antigen

  • EpitopeThis antibody recognises amino acid residues 1-80 of Hepatitis C Core Antigen.

Properties

Applications

Our Abpromise guarantee covers the use of ab2582 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
IP
  • Application notesWestern blot: 1:1000 suggested dilution.
    ELISA: 1:10,000 suggested dilution.
    Optimal working dilutions are best determined by the investigator.
  • Target

    • RelevanceThe hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.
    • Cellular localizationEndoplasmic reticulum
    • Alternative names
      • Core protein p19 antibody
      • HCV core antigen antibody
      • HCV core protein antibody
      • Hepatitis C Virus core protein antibody

    References for Anti-Hepatitis C Virus Core Antigen antibody [1E5] (ab2582)

    ab2582 has not yet been referenced specifically in any publications.

    Product Wall

    Thank you for your enquiry. Two antibodies against HCV, ab2582 (2 to 80 a.a. epitope) and ab2586 (81 to 120 a.a.) can be used together as a pair for Sandwich ELISA. However, these are both mouse monoclonal IgG2a and so one of these would need to be dir...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"