Anti-Hepatitis C Virus Core Antigen antibody [H6-29] (FITC) (ab123076)

Overview

  • Product nameAnti-Hepatitis C Virus Core Antigen antibody [H6-29] (FITC)
    See all Hepatitis C Virus Core Antigen primary antibodies
  • Description
    Mouse monoclonal [H6-29] to Hepatitis C Virus Core Antigen (FITC)
  • ConjugationFITC. Ex: 493nm, Em: 528nm
  • Specificityab123076 recognizes Hepatitis C Virus Core protein.
  • Tested applicationsSuitable for: IHC-FoFr, WB, ELISA, ICC/IFmore details
  • Species reactivity
    Reacts with: Hepatitis C Virus
  • Immunogen

    Recombinant fragment corresponding to Hepatitis C Virus Hepatitis C Virus Core Antigen aa 13-124.

  • Positive control
    • Chimpanzee liver cells infected with recombinant vaccinia virus containing a Hepatitis C Virus genome cDNA, Tissue section from a patient with chronic hepatitis C
  • General notes

    Ratio [FITC] / [IgG] = 6.7

Properties

Applications

Our Abpromise guarantee covers the use of ab123076 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-FoFr Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Detects a band of approximately 22 kDa.
ELISA Use at an assay dependent concentration.
ICC/IF Use at an assay dependent concentration.

Target

  • RelevanceThe hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.
  • Cellular localizationEndoplasmic reticulum
  • Database links
    • Alternative names
      • Core protein p21 antibody
      • HCV core antigen antibody
      • HCV core protein antibody
      • Hepatitis C Virus core protein antibody

    Anti-Hepatitis C Virus Core Antigen antibody [H6-29] (FITC) images

    • Anti-Hepatitis C Virus Core Antigen antibody [H6-29] (FITC) (ab123076) + Chimpanzee liver cells infected with recombinant vaccinia virus containing a HCV genome cDNAThe core protein is detected as a 22kDa band.
    • Detection of Hepatitis C Virus core protein by immuno- fluorescence antibody staining. Chimpanzee liver cells were infected with recombinant vaccinia virus containing a Hepatitis C Virus genome cDNA. After incubation for 48 hr, the cells were fixed with acetone and Hepatitis C Virus was detected by indirect immunofluorescence staining using ab123076.

    References for Anti-Hepatitis C Virus Core Antigen antibody [H6-29] (FITC) (ab123076)

    ab123076 has not yet been referenced specifically in any publications.

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