Hepatitis C Virus genotype 3a NS5 protein (ab68626)

Overview

  • Product nameHepatitis C Virus genotype 3a NS5 protein
  • Protein lengthFull length protein
  • Description
    Recombinant Hepatitis C Virus genotype 3a NS5 protein

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • Additional sequence informationThe E.coli derived recombinant protein fused to a GST tag contains the HCV NS5 Genotype 3 immunodominant regions.

Specifications

Our Abpromise guarantee covers the use of ab68626 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityab68626 is immunoreactive with sera of HCV-infected individuals.
  • Applications

    Western blot

    ELISA

  • Purity> 95 % SDS-PAGE.
    ab68626 was purified by a proprietary chromatographic technique.
  • FormLiquid
  • Additional notes

    Immunoreactive with sera of HCV-infected individuals.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 1.5M Urea, 25mM Tris HCl, 1mM EDTA

General Info

  • Alternative names
    • HCV NS5
    • Hepatitis C virus NS5
    • Non structural protein 5A
    • NS5A
    • p56
    see all
  • RelevanceHCV is classified into the genus Hepacivirus of the family Flaviviridae. Like all the members of the family, HCV is an enveloped, single-stranded, positive-sense RNA virus. Its genome (about 9600 nt) is flanked at both termini by conserved, highly structured non-translated regions (NTRs) and encodes a polyprotein precursor (about 3000 aa), which is proteolytically processed by host and viral proteases to produce the structural (core, E1, E2 and p7) and non-structural (NS2, NS3, NS4A, NS4B, NS5A and NS5B) proteins of the virus. Recently, an additional protein has been identified, whose function remains unknown. NS5A is a ~56 kDa pleiotropic protein with key roles in both viral RNA replication and modulation of the physiology of the host cell. It's exact role is not currently known (2008). NS5B RNA-dependant RNA polymerase is responsible for replication of the hepatitis C viral genome, and is currently a principal target for chemotherapeutic inhibition of HCV replication.

References for Hepatitis C Virus genotype 3a NS5 protein (ab68626)

ab68626 has not yet been referenced specifically in any publications.

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