Hepatitis C Virus Hepatitis C Virus Core Antigen full length protein (ab49019)

Overview

Description

  • NatureRecombinant
  • SourceE. coli
  • Amino Acid Sequence
    • SpeciesHepatitis C Virus
    • Amino acids2 to 192
  • ConjugationRhodamine. Ex: 550nm, Em: 570nm

Specifications

Our Abpromise guarantee covers the use of ab49019 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityReacts strongly with human HCV positive serum.
  • Applications

    SDS-PAGE

    ELISA

  • Purity> 95 % by SDS-PAGE.

  • FormLiquid
  • Additional NotesReacts strongly with human HCV positive serum.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 8M Urea, 20mM Tris HCl, 10mM Beta mercaptoethanol, pH 8

General info

  • Alternative names
    • Core protein p19
    • HCV core antigen
    • HCV core protein
    • Hepatitis C Virus core protein
  • RelevanceThe hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.
  • Cellular localizationEndoplasmic reticulum

References for Hepatitis C Virus Hepatitis C Virus Core Antigen full length protein (ab49019)

ab49019 has not yet been referenced specifically in any publications.

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