Anti-Hepatitis C Virus NS4 antibody [497] (ab19052)

Overview

  • Product nameAnti-Hepatitis C Virus NS4 antibody [497]
    See all Hepatitis C Virus NS4 primary antibodies
  • Description
    Mouse monoclonal [497] to Hepatitis C Virus NS4
  • Specificityab19052 reacts with synthetic NS4a Protein (1689a.a.-1735a.a.) and recombinant Chimeric HCV Polyprotein (60 kDa). No cross reaction with synthetic recombinant Capsid Protein C + Envelope Protein M (core) (1a.a.-142a.a.), synthetic Capsid Protein C (1a.a.-61a.a.), recombinant NS3 Protein (1252a.a.-1477a.a.) and synthetic NS3 Protein (1378a.a.-1458a.a.)
  • Tested applicationsSuitable for: ELISA, WBmore details
  • Immunogen

    Recombinant full length protein (Purified recombinant Chimeric HCV Polyprotein, 555aa)

Properties

Applications

Our Abpromise guarantee covers the use of ab19052 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
WB
  • Application notesELISA: Use at an assay dependent dilution.
    WB: Use at a concentration of 0.5 µg/ml. Detects Recombinant Chimeric
    HCV Polyprotein at a band of approximately 60 kDa (predicted molecular weight: 60 kDa).

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceNS4 A/B are two of the seven nonstructural (NS) proteins making up the HCV polyprotein. The NS proteins recruit the viral genome into an RNA replication complex, which is associated with rearranged cytoplasmic membranes. NS4A acts as a cofactor with the NS3 serine protease and stabilizes its folding. The NS3-NS4A complex is essential for the activation of the latter and allows membrane anchorage of NS3. HCV is a positive, single-stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. HCV is responsible for a large proportion of worldwide chronic viral hepatitides. Most of these infections develop into chronic hepatitis, which often progresses to liver cirrhosis and hepatocellular carcinoma. At present, (unlike hepatitis A and B), there is no vaccine to prevent hepatitis C infection. The hepatitis C virus (HCV) nonstructural protein 4B (NS4B) is a relatively hydrophobic 27-kDa protein. The 4A protein has a molecular weight of 6 kDa.
    • Cellular localizationEndoplasmic reticulum; multi-pass membrane protein.
    • Alternative names
      • HCV antibody
      • HCV NS4 antibody
      • Hepatitis C Virus nonstructural antigen 4 antibody
      • Non structural protein 4A antibody
      • Non structural protein 4B antibody
      • NS4A antibody
      • NS4B antibody
      • p27 antibody
      • p8 antibody
      see all

    References for Anti-Hepatitis C Virus NS4 antibody [497] (ab19052)

    ab19052 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab19052.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"