Hepatitis C Virus NS4A +B protein fragment (ab78143)

Overview

  • Product nameHepatitis C Virus NS4A +B protein fragment
  • DescriptionHepatitis C Virus NS4A +B protein fragment

Description

  • NatureRecombinant
  • SourceE. coli
  • Amino Acid Sequence
    • Amino acids1658 to 1863
  • ConjugationFITC. Ex: 493nm, Em: 528nm

Specifications

Our Abpromise guarantee covers the use of ab78143 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityReacts strongly with human HCV positive serum.
  • Applications

    Western blot

    ELISA

  • Purity> 95 % by SDS-PAGE.

  • FormLiquid
  • Additional NotesReacts strongly with human HCV positive serum.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 8M Urea, 20mM Tris HCl, 10mM Beta mercaptoethanol, pH 8

General info

  • RelevanceHepatitis C virus (HCV) is a small (55-65 nm in size), enveloped, positive sense single strand RNA virus in the family Flaviviridae. The structure of the hepatitis C virus consists of a core of genetic material (RNA), surrounded by an icosahedral protective shell of protein, and further encased in a lipid (fatty) envelope of cellular origin. Two viral envelope glycoproteins, E1 and E2, are embedded in the lipid envelope. Hepatitis C virus has a positive sense RNA genome that consists of a single open reading frame of 9600 nucleoside bases. At the 5' and 3' ends of the RNA are the UTR regions, that are not translated into proteins but are important to translation and replication of the viral RNA. The 5' UTR has a ribosome binding site (IRES - Internal Ribosomal Entry Site) that starts the translation of a 3000 amino acid containing protein that is later cut by cellular and viral proteases into 10 active structural and non-structural smaller proteins. NS4A is a non-structural viral protein that binds to a portion of HCV protease, inhibits HCV replication.

References for Hepatitis C Virus NS4A +B protein fragment (ab78143)

ab78143 has not yet been referenced specifically in any publications.

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