FormLyophilised:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
RelevanceHERC3 (Hect domain and RLD 3) belongs to the HERC family of ubiquitin ligases which contain a HECT domain and at least 1 RCC1-like domain (RLD). E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. The RLD domain is predicted to act as a guanine nucleotide exchange factor for small G proteins.
Cellular localizationCytoplasmic. Cytoplasmic vesicle. Note: Also found in vesicular-like structures.