Anti-HERV-FRD antibody - N-terminal (ab171382)

Overview

  • Product name
    Anti-HERV-FRD antibody - N-terminal
    See all HERV-FRD primary antibodies
  • Description
    Rabbit polyclonal to HERV-FRD - N-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human HERV-FRD aa 78-107 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: P60508

  • Positive control
    • NCI-H460 cell line lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99.91% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab171382 antibody is purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab171382 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 59.5 kDa.

Target

  • Function
    Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties. Can make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity.
    SU mediates receptor recognition.
    TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane.
  • Tissue specificity
    Expressed at higher level in placenta. Expressed at lower level in adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea.
  • Sequence similarities
    Belongs to the gamma type-C retroviral envelope protein family. HERV class-I FRD env subfamily.
  • Domain
    Contains the CKS-17 immunosuppressive domain present in many retroviral envelope proteins. As a synthetic peptide, it inhibits immune function in vitro and in vivo.
  • Post-translational
    modifications
    Specific enzymatic cleavages in vivo yield the mature SU and TM proteins.
    The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion.
  • Cellular localization
    Cell membrane and Virion.
  • Information by UniProt
  • Database links
  • Alternative names
    • EFRD1_HUMAN antibody
    • Endogenous retrovirus group FRD member 1 antibody
    • Envelope polyprotein antibody
    • ERVFRD-1 antibody
    • FLJ41944 antibody
    • FLJ90611 antibody
    • GLLL6191 antibody
    • HERV FRD 6p24.1 provirus ancestral Env polyprotein antibody
    • HERV FRD antibody
    • HERV FRD provirus ancestral Env polyprotein antibody
    • HERV-FRD antibody
    • HERVFRD antibody
    • HERVFRD provirus ancestral Env polyprotein antibody
    • MGC87585 antibody
    • SU antibody
    • Syncytin 2 antibody
    • Syncytin B antibody
    • Syncytin-2 antibody
    • TM antibody
    • Transmembrane protein antibody
    • UNQ6191 antibody
    see all

Images

  • Anti-HERV-FRD antibody - N-terminal (ab171382) at 1/100 dilution + NCI-H460 cell line lysate at 35 µg

    Predicted band size: 59.5 kDa

References

ab171382 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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