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Storage instructions Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer Preservative: None
PBS, pH 7.2
Concentration information loading...
Purity Protein G purified
Light chain type kappa
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notes WB: Use at a concentration of 1-5 µg/ml. This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Function Transcriptional repressor of genes that require a bHLH protein for their transcription.
Tissue specificity Expressed in placenta, pancreatic cancer, colon cancer with RER, cervical cancer, and in head and neck tumors.
Sequence similarities Contains 1 bHLH (basic helix-loop-helix) domain. Contains 1 Orange domain.
Domain Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG). The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
Cellular localization Nucleus.
Information by UniProt
Class B basic helix loop helix protein 40 antibody
Anti-HES2 antibody images
References for Anti-HES2 antibody (ab57396)
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"