Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab57396 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionTranscriptional repressor of genes that require a bHLH protein for their transcription.
    • Tissue specificityExpressed in placenta, pancreatic cancer, colon cancer with RER, cervical cancer, and in head and neck tumors.
    • Sequence similaritiesContains 1 bHLH (basic helix-loop-helix) domain.
      Contains 1 Orange domain.
    • DomainHas a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
      The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • antibody
      • bHLHb40 antibody
      • Class B basic helix loop helix protein 40 antibody
      • Class B basic helix-loop-helix protein 40 antibody
      • Hairy and enhancer of split 2 (Drosophila) antibody
      • Hairy and enhancer of split 2 antibody
      • Hes2 antibody
      • HES2_HUMAN antibody
      • Transcription factor HES 2 antibody
      • Transcription factor HES-2 antibody
      see all

    Anti-HES2 antibody images

    • Western blot against tagged recombinant protein immunogen using ab57396 HES2 antibody at 1ug/ml. Predicted band size of immunogen is 34 kDa

    References for Anti-HES2 antibody (ab57396)

    ab57396 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"