Anti-HES5 antibody (ab107593)

Overview

• Product nameAnti-HES5 antibody
  See all HES5 primary antibodies
• Description
  Rabbit polyclonal to HES5
• Tested applicationsSuitable for: WB, IHC-Pmore details
• Species reactivity
  Reacts with: Mouse, Rat, Human
  
• Immunogen

  Synthetic peptide, corresponding to a region within N terminal amino acids 1-50 of Human HES5 (Q5TA89)

• Positive control
  • Mouse liver tissue lysate and Human brain tissue

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
• Storage bufferPreservative: 0.05% Sodium Azide
  Constituents: 0.05% BSA, PBS
• Concentration information loading...
• PurityProtein A purified
• ClonalityPolyclonal
• IsotypeIgG
• Research areas
  • Neuroscience
  • Neurology process
  • Notch Pathway

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Domain Families
  • HLH / Leucine Zipper
  • HLH

  • Stem Cells
  • Signaling Pathways
  • Notch
  • Nuclear

  • Stem Cells
  • Neural Stem Cells
  • Intracellular

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Transcription Factors

Associated products

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

Applications

Target

• FunctionTranscriptional repressor of genes that require a bHLH protein for their transcription.
• Tissue specificityExpressed in fetal heart and brain tumors.
• Sequence similaritiesContains 1 basic helix-loop-helix (bHLH) domain.
  Contains 1 Orange domain.
• DomainHas a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
  The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
• Cellular localizationNucleus.

• Target information above from: UniProt accession Q5TA89 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 388585 Human
  • Entrez Gene: 15208 Mouse
  • Entrez Gene: 79225 Rat
  • Omim: 607348 Human
  • SwissProt: Q5TA89 Human
  • SwissProt: P70120 Mouse
  • SwissProt: Q03062 Rat
  • Unigene: 57971 Human

  • Unigene: 137268 Mouse
  • Unigene: 22422 Rat

  see all
• Alternative names
  • bHLHb38 antibody
  • Class B basic helix-loop-helix protein 38 antibody
  • Hairy and enhancer of split 5 antibody

  • Hairy/Enhancer of spli, Drosophila, homolog of, 5 antibody
  • HES 5 antibody
  • hes family bHLH transcription factor 5 antibody
  • Hes5 antibody
  • HES5 protein antibody
  • HES5_HUMAN antibody
  • MGI:104876 antibody
  • Transcription factor HES-5 antibody

  see all