RelevanceHES6 is a transcription cofactor that iteself does not bind to DNA but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. It also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCFEA2/E47, allowing ASCL1 and TCFEA2 to upregulate transcription in its presence.
HES6 appears to have novel functions in tumour and cancer cell lines, although these have not yet been elucidated fully.
Class B basic helix-loop-helix protein 41 antibody
Hairy and enhancer of split 6 antibody
HES 6 antibody
Transcription cofactor HES6 antibody
References for Anti-HES6 antibody (ab66461)
This product has been referenced in:
Methot L et al. Interaction and Antagonistic Roles of NF-?B and Hes6 in the Regulation of Cortical Neurogenesis. Mol Cell Biol33:2797-808 (2013).
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Haapa-Paananen S et al. HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation. Oncogene : (2011).
Read more (PubMed: 21785461) »