Overview

  • Product nameAnti-HES6 antibody
    See all HES6 primary antibodies
  • Description
    Rabbit polyclonal to HES6
  • Tested applicationsSuitable for: IHC-P, WB, IHC-Frmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide derived from the C-terminal of Human HES6

Properties

Applications

Our Abpromise guarantee covers the use of ab66461 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.
WB 1/500 - 1/5000. Predicted molecular weight: 24 kDa.
IHC-Fr Use at an assay dependent concentration.

Target

  • RelevanceHES6 is a transcription cofactor that iteself does not bind to DNA but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. It also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCFEA2/E47, allowing ASCL1 and TCFEA2 to upregulate transcription in its presence. HES6 appears to have novel functions in tumour and cancer cell lines, although these have not yet been elucidated fully.
  • Cellular localizationNuclear
  • Database links
  • Alternative names
    • bHLHb41 antibody
    • bHLHc23 antibody
    • C HAIRY1 antibody
    • Class B basic helix-loop-helix protein 41 antibody
    • Hairy and enhancer of split 6 antibody
    • HES 6 antibody
    • Transcription cofactor HES6 antibody
    see all

References for Anti-HES6 antibody (ab66461)

This product has been referenced in:
  • Methot L  et al. Interaction and Antagonistic Roles of NF-?B and Hes6 in the Regulation of Cortical Neurogenesis. Mol Cell Biol 33:2797-808 (2013). IHC-Fr ; Mouse . Read more (PubMed: 23689134) »
  • Haapa-Paananen S  et al. HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation. Oncogene : (2011). ICC/IF ; Human . Read more (PubMed: 21785461) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"