Overview

  • Product nameAnti-HEXA antibody
    See all HEXA primary antibodies
  • Description
    Rabbit polyclonal to HEXA
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    KLH conjugated synthetic peptide selected from the central region of Human HEXA (NP_000511.2).

  • Positive control
    • HepG2 cell line lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab93111 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notesELISA: 1/1000.
    WB: 1/100 - 1/500. Predicted molecular weight: 61 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionResponsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. The form B is active against certain oligosaccharides. The form S has no measurable activity.
    • Involvement in diseaseDefects in HEXA are the cause of GM2-gangliosidosis type 1 (GM2G1) [MIM:272800]; also known as Tay-Sachs disease. GM2-gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2G1 is characterized by GM2 gangliosides accumulation in the absence of HEXA activity, leading to neurodegeneration and, in the infantile form, death in early childhood. GM2G1 has an increased incidence among Ashkenazi Jews and French Canadians in eastern Quebec. It exists in several forms: infantile (most common and most severe), juvenile and adult (late onset).
    • Sequence similaritiesBelongs to the glycosyl hydrolase 20 family.
    • Post-translational
      modifications
      N-linked glycan at Asn-115 consists of Man(3)-GlcNAc(2).
    • Cellular localizationLysosome.
    • Information by UniProt
    • Database links
    • Alternative names
      • Beta hexosaminidase alpha chain precursor antibody
      • Beta hexosaminidase subunit alpha antibody
      • Beta N acetylhexosaminidase antibody
      • Beta N acetylhexosaminidase subunit alpha antibody
      • Beta-hexosaminidase A antibody
      • Beta-hexosaminidase subunit alpha antibody
      • Beta-N-acetylhexosaminidase subunit alpha antibody
      • Hexa antibody
      • HEXA_HUMAN antibody
      • Hexosaminidase A (alpha polypeptide) antibody
      • Hexosaminidase A alpha polypeptide antibody
      • Hexosaminidase A antibody
      • Hexosaminidase subunit A antibody
      • MGC99608 antibody
      • N acetyl beta glucosaminidase antibody
      • N acetyl beta glucosaminidase subunit alpha antibody
      • N-acetyl-beta-glucosaminidase subunit alpha antibody
      • TSD antibody
      see all

    Anti-HEXA antibody images

    • Anti-HEXA antibody (ab93111) at 1/100 dilution + HepG2 cell line lysates at 35 µg

      Predicted band size : 61 kDa

    References for Anti-HEXA antibody (ab93111)

    ab93111 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab93111.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"