Overview

  • Product name
    Anti-HEXB antibody - C-terminal
    See all HEXB primary antibodies
  • Description
    Rabbit polyclonal to HEXB - C-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide derived from the C terminus of Human HEXB.

  • Positive control
    • Human brain cortex tissue; Jurkat cell extract.

Properties

Applications

Our Abpromise guarantee covers the use of ab166791 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 63 kDa.
IHC-P Use a concentration of 5 µg/ml.

Target

  • Function
    Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.
  • Involvement in disease
    Defects in HEXB are the cause of GM2-gangliosidosis type 2 (GM2G2) [MIM:268800]; also known as Sandhoff disease. GM2-gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2G2 is clinically indistinguishable from GM2-gangliosidosis type 1, presenting startle reactions, early blindness, progressive motor and mental deterioration, macrocephaly and cherry-red spots on the macula.
  • Sequence similarities
    Belongs to the glycosyl hydrolase 20 family.
  • Post-translational
    modifications
    N-linked glycans at Asn-142 and Asn-190 consist of Man(3)-GlcNAc(2) and Man(5 to 7)-GlcNAc(2), respectively.
    The beta-A and beta-B chains are produced by proteolytic processing of the precursor beta chain.
  • Cellular localization
    Lysosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • Beta hexosaminidase beta chain antibody
    • Beta hexosaminidase subunit beta antibody
    • Beta N acetylhexosaminidase antibody
    • Beta-hexosaminidase subunit beta chain A antibody
    • Beta-N-acetylhexosaminidase subunit beta antibody
    • Cervical cancer proto oncogene 7 protein antibody
    • Cervical cancer proto-oncogene 7 protein antibody
    • ENC 1AS antibody
    • Epididymis luminal protein 248 antibody
    • HCC 7 antibody
    • HCC-7 antibody
    • HCC7 antibody
    • HEL 248 antibody
    • HEX B antibody
    • Hexb antibody
    • HEXB_HUMAN antibody
    • Hexosaminidase B (beta polypeptide) antibody
    • Hexosaminidase B antibody
    • Hexosaminidase subunit B antibody
    • HexosaminidaseB antibody
    • N acetyl beta glucosaminidase antibody
    • N-acetyl-beta-glucosaminidase subunit beta antibody
    see all

Images

  • All lanes : Anti-HEXB antibody - C-terminal (ab166791) at 1/500 dilution

    Lane 1 : Jurkat cell extract
    Lane 2 : Jurkat cell extract with immunizing peptide

    Predicted band size: 63 kDa

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain cortex tissue labeling HEXB with ab166791 at 5 µg/ml.

References

ab166791 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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