Overview

  • Product name
  • Description
    Rabbit polyclonal to HEXO
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide derived from Human HEXO.

  • Positive control
    • Rat brain lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab93385 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    WB: 1/500 - 1/3000. Detects a band of approximately 40 kDa (predicted molecular weight: 40 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.
    • Sequence similarities
      Contains 1 exonuclease domain.
      Contains 1 SAP domain.
    • Domain
      The SAP domain is necessary for binding to the stem-loop structure of histone mRNAs and to form the ternary complex with SLBP, but not for 3'-end histone mRNA exonuclease activity.
    • Cellular localization
      Cytoplasm. Nucleus. Nucleus > nucleolus.
    • Information by UniProt
    • Database links
    • Alternative names
      • 3' 5' exonuclease ERI 1 antibody
      • 3' 5' exonuclease ERI1 antibody
      • 3' EXO antibody
      • 3' exoribonuclease antibody
      • 3' HEXO antibody
      • 3' histone mRNA exonuclease 1 antibody
      • 3''-5'' exonuclease eri1 antibody
      • 3''-5'' exoribonuclease 1 antibody
      • 3'EXO antibody
      • 3'HEXO antibody
      • ERI 1 antibody
      • Eri 1 homolog antibody
      • Eri-1 homolog antibody
      • eri1 antibody
      • Eri1 homolog antibody
      • ERI1_HUMAN antibody
      • HEXO antibody
      • Histone mRNA 3' end specific exonuclease antibody
      • Histone mRNA 3' end specific exoribonuclease antibody
      • Histone mRNA 3''-end-specific exoribonuclease antibody
      • Histone mRNA 3''-exonuclease 1 antibody
      • MGC35395 antibody
      • Protein 3''hExo antibody
      • THEX 1 antibody
      • THEX1 antibody
      • Three prime histone mRNA exonuclease 1 antibody
      see all

    Images

    • All lanes : Anti-HEXO antibody (ab93385) at 1/1000 dilution

      Lane 1 : Rat brain lysate
      Lane 2 : Rat brain lysate

      Lysates/proteins at 84 µg per lane.


      Predicted band size : 40 kDa
      Observed band size : 40 kDa

    References

    ab93385 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab93385.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

    Sign up