Overview

  • Product name
    Anti-Hexokinase II antibody
    See all Hexokinase II primary antibodies
  • Description
    Rabbit polyclonal to Hexokinase II
  • Specificity
    ab78259 reacts with the Hexokinase II (102 kDa). No reactivity with the Type I or Type III isozymes is observed by immunoblot or ELISA.
  • Tested applications
    Suitable for: WB, ELISA, ICC/IFmore details
  • Species reactivity
    Reacts with: Rat, Hamster, Human
    Predicted to work with: Mammal
  • Immunogen

    Recombinant full length Hexokinase II protein (Rat)

  • Positive control
    • Insulin-responsive tissues such as skeletal muscle.

Properties

Applications

Our Abpromise guarantee covers the use of ab78259 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/5000 - 1/10000. Predicted molecular weight: 102 kDa.
ELISA Use at an assay dependent dilution.
ICC/IF Use at an assay dependent dilution.

Target

  • Tissue specificity
    Predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle.
  • Pathway
    Carbohydrate metabolism; hexose metabolism.
  • Sequence similarities
    Belongs to the hexokinase family.
    Contains 2 hexokinase domains.
  • Domain
    The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus. Each domain can bind a single glucose and Gluc-6-P molecule.
  • Cellular localization
    Mitochondrion outer membrane. Its hydrophobic N-terminal sequence may be involved in membrane binding.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZp686M1669 antibody
    • Hexokinase 2 antibody
    • Hexokinase 2 muscle antibody
    • Hexokinase type II antibody
    • Hexokinase-2 antibody
    • HK 2 antibody
    • HK II antibody
    • HK2 antibody
    • HKII antibody
    • HxK 2 antibody
    • HxK2 antibody
    • HXK2_HUMAN antibody
    • Muscle form hexokinase antibody
    see all

Images



  • Predicted band size : 102 kDa

References

This product has been referenced in:
  • Waskova-Arnostova P  et al. Chronic hypoxia enhances expression and activity of mitochondrial creatine kinase and hexokinase in the rat ventricular myocardium. Cell Physiol Biochem 33:310-20 (2014). Read more (PubMed: 24525799) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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