Anti-HEY2 antibody (ab167280)
Key features and details
- Mouse polyclonal to HEY2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-HEY2 antibody
See all HEY2 primary antibodies -
Description
Mouse polyclonal to HEY2 -
Host species
Mouse -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse -
Immunogen
Recombinant full length protein within Human HEY2 aa 1-350. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
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Positive control
- HEY2 transfected 293T cell lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
pH: 7.4
Constituent: 99% PBS -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab167280 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (1) |
Use a concentration of 1 µg/ml. Predicted molecular weight: 36 kDa.
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Notes |
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WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 36 kDa. |
Target
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Function
Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. -
Sequence similarities
Belongs to the HEY family.
Contains 1 basic helix-loop-helix (bHLH) domain.
Contains 1 Orange domain. -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 23493 Human
- Entrez Gene: 15214 Mouse
- Omim: 604674 Human
- SwissProt: Q9UBP5 Human
- SwissProt: Q9QUS4 Mouse
- Unigene: 144287 Human
- Unigene: 103573 Mouse
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Alternative names
- bHLHb32 antibody
- Cardiovascular helix loop helix factor 1 antibody
- Cardiovascular helix-loop-helix factor 1 antibody
see all
Images
Datasheets and documents
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Datasheet download
References (6)
ab167280 has been referenced in 6 publications.
- Du Z et al. SOX8 Knockdown Overcomes Enzalutamide Resistance in Castration-Resistant Prostate Cancer by Inhibiting the Notch Signaling Pathway. Biomed Res Int 2022:9235837 (2022). PubMed: 36246971
- Bai J et al. Angiogenic responses in a 3D micro-engineered environment of primary endothelial cells and pericytes. Angiogenesis 24:111-127 (2021). PubMed: 32955682
- Gordon-Weeks A et al. Tumour-Derived Laminin a5 (LAMA5) Promotes Colorectal Liver Metastasis Growth, Branching Angiogenesis and Notch Pathway Inhibition. Cancers (Basel) 11:N/A (2019). PubMed: 31064120
- Zhang B et al. A regulatory circuit of circ-MTO1/miR-17/QKI-5 inhibits the proliferation of lung adenocarcinoma. Cancer Biol Ther 20:1127-1135 (2019). PubMed: 30975029
- Yan Y et al. HIF-2a promotes conversion to a stem cell phenotype and induces chemoresistance in breast cancer cells by activating Wnt and Notch pathways. J Exp Clin Cancer Res 37:256 (2018). PubMed: 30340507
- Ang YS et al. Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human Cardiogenesis. Cell 167:1734-1749.e22 (2016). PubMed: 27984724