The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 2 µg/ml. Detects a band of approximately 39 kDa (predicted molecular weight: 36 kDa).
FunctionDownstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
Sequence similaritiesBelongs to the HEY family. Contains 1 basic helix-loop-helix (bHLH) domain. Contains 1 Orange domain.
Redmond EM et al. Perivascular delivery of Notch 1 siRNA inhibits injury-induced arterial remodeling. PLoS One9:e84122 (2014).
Read more (PubMed: 24416200) »
Hu GH et al. Delta-like ligand 4 (Dll4) predicts the prognosis of clear cell renal cell carcinoma, and anti-Dll4 suppresses tumor growth in vivo. Int J Clin Exp Pathol7:2143-52 (2014).
Read more (PubMed: 24966922) »