Overview

  • Product nameAnti-HFE antibody
    See all HFE primary antibodies
  • Description
    Rabbit polyclonal to HFE
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Horse, Chimpanzee
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 35-84 (MGASEQDLGL SLFEALGYVD DQLFVFYDHE SRRVEPRTPW VSSRISSQMW) of Human HFE (NP_000401).

  • Positive control
    • HeLa cell lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab102592 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 40 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionBinds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
  • Tissue specificityExpressed in all tissues tested except brain.
  • Involvement in diseaseDefects in HFE are a cause of hemochromatosis (HFE) [MIM:235200]. A disorder of iron metabolism characterized by iron overload. Excess iron is deposited in a variety of organs leading to their failure, and resulting in serious illnesses including cirrhosis, hepatomas, diabetes, cardiomyopathy, arthritis, and hypogonadotropic hypogonadism. Severe effects of the disease usually do not appear until after decades of progressive iron loading.
    Defects in HFE are associated with variegate porphyria (VP) [MIM:176200]. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. VP is the most common form of porphyria in South Africa. It is characterized by skin hyperpigmentation and hypertrichosis, abdominal pain, tachycardia, hypertension and neuromuscular disturbances. High fecal levels of protoporphyrin and coproporphyrin, increased urine uroporphyrins and iron overload are typical markers of the disease. Note=Iron overload due to HFE mutations is a precipitating or exacerbating factor in variegate porphyria.
    Defects in HFE are associated with susceptibility to microvascular complications of diabetes type 7 (MVCD7) [MIM:612635]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
  • Sequence similaritiesBelongs to the MHC class I family.
    Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • dJ221C16.10.1 antibody
    • Hemochromatosis antibody
    • Hemochromatosis protein antibody
    • Hereditary hemochromatosis protein antibody
    • Hereditary hemochromatosis protein HLA H antibody
    • HFE 1 antibody
    • HFE antibody
    • HFE_HUMAN antibody
    • HFE1 antibody
    • HH antibody
    • High Fe antibody
    • HLA H antibody
    • HLA-H antibody
    • HLAH antibody
    • MGC:150812 antibody
    • MGC10379 antibody
    • MGC103790 antibody
    • MHC class I like protein HFE antibody
    • MVCD7 antibody
    • TFQTL2 antibody
    see all

Anti-HFE antibody images

  • Anti-HFE antibody (ab102592) at 1 µg/ml + HeLa cell lysate at 10 µg

    Predicted band size : 40 kDa

References for Anti-HFE antibody (ab102592)

ab102592 has not yet been referenced specifically in any publications.

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