HGFA Inhibitor 1 antibody - KDI insert (ab28332)

Product Name 

HGFA Inhibitor 1 antibody - KDI insert

Product type 

Primary antibodies

Description 

Rabbit polyclonal to HGFA Inhibitor 1 - KDI insert

Immunogen 

Synthetic peptide based on the insert after the KD1 domain of human HGFA Inhibitor 1 sequence.

(Peptide available as ab41269.)

Reacts with 
(species key)

Hu

Specificity 

This antibody is specific for HGFA Inhibitor 1 and HAI-1B (a splice variant).

We have a range of domain specific antibodies for this target. For a full list please see all HGFA Inhibitor 1 antibodies

Tested applications 
(see key)

WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
WB: 1/1000 when using colorimetric substrates such as BCIP/NBT and 1/5000 for chemiluminescent substrates. Detects bands of approximately 58kDa and 40kDa (predicted molecular weight: 58kDa). Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Cell Membrane and Secreted

Research areas 

Cell Biology >> Proteolysis / Ubiquitin >> Protease inhibitors >> Serine protease inhibitors >> HAIs
Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> Other
Immunology >> Secreted Molecules >> Other secreted molecules

Relevance 

HGFA Inhibitor 1 is an endogenous inhibitor of the kunitz-type serine proteinase HGF-activator (HGFA). HGF was first described as a hepatocyte-specific mitogen and survival factor, and has since been shown to exert a variety of actions on many cell types by binding to its MET receptor. HGF is activated by cleavage of the single-chain form to form a two-chain version by HGFA. HGFA Inhibitor 1 also inhibits trypsin, and MTSP-1 (Matriptase), a serine proteinase that also activates HGF. HGFB Inhibitor 1 is a splice variant of HGFA Inhibitor 1, and contains a 16 amino acid insert after the first kringle domain, relative to the HGFA Inhibitor 1 sequence.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Immunogen affinity purified

Storage buffer 

Preservative: 0.05% Sodium Azide
Constituents: 50% Glycerol

Material safety datasheets (MSDS) for this product:
Glycerol MSDS
Sodium Azide MSDS

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

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