HGFA Inhibitor 2 antibody - Between KD1 and KD2 (ab28334)

Product Name 

HGFA Inhibitor 2 antibody - Between KD1 and KD2

Product type 

Primary antibodies

Description 

Rabbit polyclonal to HGFA Inhibitor 2 - Between KD1 and KD2

Immunogen 

Synthetic peptide based on the human HGFA Inhibitor 2 sequence.(Peptide available as ab41272.)

Reacts with 
(species key)

Hu

Specificity 

This antibody is specific for HGFA Inhibitor 2. It will not recognize HGFA Inhibitor 1.

We have a range of domain specific antibodies for this target. For a full list please see all HGFA Inhibitor 2 antibodies

Tested applications 
(see key)

WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
WB: 1/1000 when using colorimetric substrates such as BCIP/NBT and 1/5000 for chemiluminescent substrates. Detects a band of approximately 22-32 kDa due to post-translational modifications (predicted molecular weight: 28 kDa). Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Cell Membrane; single-pass type I membrane protein and Secreted.

Research areas 

Developmental Biology >> Reproduction >> Placental development
Cell Biology >> Proteolysis / Ubiquitin >> Protease inhibitors >> Serine protease inhibitors >> HAIs

Neuroscience >> Neurology process >> Neurogenesis

Relevance 

HGFA Inhibitor 2 is an endogenous inhibitor of the kunitz-type serine proteinase HGF-activator (HGFA). HGF was first described as a hepatocyte-specific mitogen and survival factor, and has since been shown to exert a variety of actions on many cell types by binding to its MET receptor. HGF is activated by cleavage of the single-chain form to form a two-chain version by HGFA. HGFA Inhibitor 2 also inhibits trypsin, and MTSP-1 (Matriptase-1), a serine proteinase that also activates HGF, and HGF-2 has been shown to inhibit hepsin with nanamolar kIs. HGFA Inhibitor 2 was first known as bikunin, and SPINT2 (Serine Proteinase Inhibitor-2), a proteinase inhibitor found in amniotic fluid.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Immunogen affinity purified

Storage buffer 

Preservative: 0.05% Sodium Azide
Constituents: 50% Glycerol

Material safety datasheets (MSDS) for this product:
Glycerol MSDS
Sodium Azide MSDS

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

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